The higher incidence of autoimmune thyroid disease in prolactinomas than in somatotrophinomas

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dc.authorwosidSelcukbiricik, Ozlem Soyluk/AAT-9703-2020
dc.authorwosidYarman, Sema/AAS-7526-2020
dc.contributor.authorDogansen, Sema Ciftci
dc.contributor.authorSelcukbiricik, Ozlem Soyluk
dc.contributor.authorBilir, Betul Ekiz
dc.contributor.authorYarman, Sema
dc.date.accessioned2024-06-12T10:54:04Z
dc.date.available2024-06-12T10:54:04Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Many studies have shown that prolactin (PRL) plays an important role in autoimmune diseases. The aim of this study was to compare the current frequency of autoimmune thyroid disease (ATD) in prolactinomas with another type of functional pituitary adenoma (FPA), somatotrophinoma. Another aim of the study was to evaluate possible factors related to thyroid autoimmunity and, the process of ATD in FPAs. Methods: We retrospectively evaluated the presence of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) and thyroid morphologic findings in our patients with FPA (78 with acromegaly and 83 With prolactinoma). The relationship of autoantibody positivity with baseline PRL levels, activity of acromegaly, and treatment of dopamine agonists (DA) and hypogonadism was also assessed. Patients with ATD and hypothyroidism due to autoimmune thyroiditis were also evaluated. Results: ATD (Hashimoto's thyroiditis) was detected more frequently in patients with prolactinoma than in patients with acromegaly (33% and 17%, respectively; p = 0.01). Thyroid autoantibody positivity was found more frequently in females in the whole group (p = 0.02) and in the acromegaly group (p = 0.008). There was no difference according to sex among the patients with prolactinoma (p = 0.800). ATD was found not to be related with baseline PRL levels, treatment of DA, and presence of hypogonadism (p = 0.232, p = 0.435, p = 0.464, respectively) in the prolactinoma group, and activity of acromegaly, presence of hypogonadism in the acromegaly group (p = 0.753, p = 0.654, respectively). Autoimmune hypothyroidism was more frequent in the prolactinoma group than in the acromegaly group among patients with thyroid autoantibody positivity (p = 0.004). Conclusion: Thyroid autoantibodies should be evaluated both at the time of diagnosis and during the course of treatment in patients with prolactinoma, and thyroid function tests should be closely monitored in patients with autoantibody positivity. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ghir.2016.04.004
dc.identifier.endpage49en_US
dc.identifier.issn1096-6374
dc.identifier.issn1532-2238
dc.identifier.pmid27105040en_US
dc.identifier.scopus2-s2.0-84963831790en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage45en_US
dc.identifier.urihttps://doi.org/10.1016/j.ghir.2016.04.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18894
dc.identifier.volume29en_US
dc.identifier.wosWOS:000381536200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofGrowth Hormone & Igf Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune Thyroid Diseaseen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.subjectProlactinomaen_US
dc.subjectHyperprolactinemiaen_US
dc.subjectSomatotrophinomaen_US
dc.subjectAcromegalyen_US
dc.subjectClinical-Practice Guidelineen_US
dc.subjectGrowth-Hormoneen_US
dc.subjectHashimotos-Thyroiditisen_US
dc.subjectCancer-Risken_US
dc.subjectHyperprolactinemiaen_US
dc.subjectSocietyen_US
dc.subjectCellsen_US
dc.subjectGlanden_US
dc.subjectBromocriptineen_US
dc.subjectActivationen_US
dc.titleThe higher incidence of autoimmune thyroid disease in prolactinomas than in somatotrophinomasen_US
dc.typeArticleen_US

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