The relation between the levels of osteoprotegerin and the degree of coronary artery disease in patients with acute coronary syndrome and stable angina pectoris

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidBarutcu, Ahmet/HKE-7359-2023
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorAksu, Feyza
dc.contributor.authorOzcelik, Fatih
dc.contributor.authorKunduracilar, Hakan
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorYel, Mesih
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorAltun, Armagan
dc.date.accessioned2024-06-12T11:11:47Z
dc.date.available2024-06-12T11:11:47Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Osteoprotegerin (OPG), an inhibitor of osteoclastogenesis, has recently been under the spotlight in studies regarding the pathophysiology of atherosclerosis. Aim: To evaluate the value of serum OPG in the diagnosis and severity in patients with stable angina pectoris (SA) and unstable angina pectoris/non ST elevation myocardial infarction. Methods: This study involved 160 patients, SA (n = 65), acute coronary syndrome (NSTE-ACS; n = 65), and a control group (n = 30). Blood samples were collected in the first hour, after 24 hours and on the fifth day. The prevalence of coronary artery atherosclerotic lesions was determined using the Gensini scoring system. Results: A statistically significant difference was observed in the first hour OPG levels between the control group and both the SA and NSTE-ACS group (p < 0.001). When the cut-off value was determined as 247.71 pg/mL, the sensitivity and specificity of the first hour OPG levels indicating coronary artery disease were 91.54% and 46.67%, respectively, while the positive predictive value was 88.1% and the negative predictive value was 56%. No correlations were observed between the first, 24th hour and the fifth day OPG levels and the Gensini scores. No relation was denoted between the OPG levels and number of diseased coronary arteries. Conclusions: In our study, serum OPG level seemed to be unrelated to the severity or the degree of coronary artery disease in patients with SA and unstable angina pectoris/non ST elevation myocardial infarction. OPG may only be accepted as an indicator of coronary artherosclerosis.en_US
dc.identifier.doi10.5603/KP.2014.0004
dc.identifier.endpage41en_US
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue1en_US
dc.identifier.pmid24469748en_US
dc.identifier.scopus2-s2.0-84893149727en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage34en_US
dc.identifier.urihttps://doi.org/10.5603/KP.2014.0004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22933
dc.identifier.volume72en_US
dc.identifier.wosWOS:000330347900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVia Medicaen_US
dc.relation.ispartofKardiologia Polskaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOsteoprotegerinen_US
dc.subjectStable Angina Pectorisen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectAortic Calcificationen_US
dc.subjectGene Polymorphismsen_US
dc.subjectBone Lossen_US
dc.subjectRanklen_US
dc.subjectOsteoporosisen_US
dc.subjectAssociationen_US
dc.subjectPredictoren_US
dc.subjectMortalityen_US
dc.subjectMenen_US
dc.subjectOpgen_US
dc.titleThe relation between the levels of osteoprotegerin and the degree of coronary artery disease in patients with acute coronary syndrome and stable angina pectorisen_US
dc.typeArticleen_US

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