Effects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in rats

Basit Öğe Kaydı
dc.authoridGunduz, Ozgur/0000-0002-2470-3021;
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorTastekin, Ebru
dc.contributor.authorKaradag, Cetin Hakan
dc.date.accessioned2024-06-12T11:00:30Z
dc.date.available2024-06-12T11:00:30Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn recent years, it has been pointed out that epigenetic changes affect learning and memory formation. Particularly, it has been shown that histone acetylation and DNA methylation work in concert to regulate learning and memory formation. We aimed to examine whether acetylation of H2B within the rat hippocampus alters by trainings in the Morris water maze test. Male, 2-3 months old, Sprague Dawley rats were trained in Morris water maze task. Animals were given four trials per day for five consecutive days to locate a hidden platform. On the sixth day, the platform was removed and the animals were swum for 60 s. The effects of sodium butyrate, histone deacetylase inhibitor, were tested on normal and scopolamine-induced memory-impaired rats. The histone deacetylase inhibitor, sodium butyrate, increased histone H2B acetylation in normal rats. Sodium butyrate had no effect on learning and memory performance of normal rats; however, it partially ameliorated learning and memory disruption induced by scopolamine. So, the histone deacetylase inhibitors can be new treatment agent for cognitive disorders.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2012/210]en_US
dc.description.sponsorshipThis work was supported by a grant from Trakya University Research Council (TUBAP-2012/210). We thank Ahmet Ulugol, Gulnur Kizilay-Ozfidan, K. Duvan-Aydemir and Zeynep Todurga for their support. The authors have no conflicts of interests to report.en_US
dc.identifier.doi10.1111/fcp.12512
dc.identifier.endpage228en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue2en_US
dc.identifier.pmid31617237en_US
dc.identifier.scopus2-s2.0-85075484010en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage222en_US
dc.identifier.urihttps://doi.org/10.1111/fcp.12512
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20864
dc.identifier.volume34en_US
dc.identifier.wosWOS:000497747500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofFundamental & Clinical Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEpigeneticen_US
dc.subjectHistone Acetylationen_US
dc.subjectLearningen_US
dc.subjectSpatial Memoryen_US
dc.subjectDeacetylase Inhibitorsen_US
dc.subjectChromatinen_US
dc.subjectImpairmenten_US
dc.subjectMechanismen_US
dc.titleEffects of hippocampal histone acetylation and HDAC inhibition on spatial learning and memory in the Morris water maze in ratsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu