The Role of Fc? Receptor Gene Polymorphism in Pediatric Renal Transplant Rejections

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dc.contributor.authorOzkayin, N.
dc.contributor.authorMir, S.
dc.contributor.authorAfig, B.
dc.date.accessioned2024-06-12T11:20:03Z
dc.date.available2024-06-12T11:20:03Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the study reported herein was to determine whether panel-reactive antibody (PRA) and Fc gamma R gene polymorphism act in the same way on acute rejection (AR) and chronic rejection (CR) in children who have undergone renal transplantation. The study evaluated 56 children who underwent transplantation and 115 healthy subjects. AR was observed in 13 cases; CR was observed in 7 patients. The assessment for Fc gamma R of the groups in which AR was present showed statistical significance only for the Fc gamma IIA genotype. There was no statistical significance for either the Fc gamma IIIA or Fc gamma IIIB genotypes. Assessment of the Fc gamma IIA, IIIA, and IIIB genotypes of the groups in whom CR was present did not show statistical significance. As a result, the prediction of graft survival among transplant recipients is possible using molecular biology. The results of our study showed that individuals of the Fc gamma RIIA genotype seemed to have a poorer prognosis similar to some autoimmune diseases. These individuals constitute a risk group for AR. If other studies are conducted with more patients to demonstrate the relationship of other Fc gamma Rs to rejection, the resultant predictive knowledge about the value of genotypes may lead to improved outcomes following renal transplantation.en_US
dc.identifier.doi10.1016/j.transproceed.2008.08.137
dc.identifier.endpage3374en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue10en_US
dc.identifier.pmid19100392en_US
dc.identifier.startpage3367en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2008.08.137
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25446
dc.identifier.volume40en_US
dc.identifier.wosWOS:000262133300020en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSystemic-Lupus-Erythematosusen_US
dc.subjectPolymerase-Chain-Reactionen_US
dc.subjectAllograft Rejectionen_US
dc.subjectRiia Polymorphismen_US
dc.subjectGraft-Survivalen_US
dc.subjectSingle-Centeren_US
dc.subjectRisk-Factorsen_US
dc.subjectAssociationen_US
dc.subjectAntibodiesen_US
dc.subjectDiseaseen_US
dc.titleThe Role of Fc? Receptor Gene Polymorphism in Pediatric Renal Transplant Rejectionsen_US
dc.typeArticleen_US

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