AN INVESTIGATION OF THE RELATIONSHIP BETWEEN THE eNOS GENE POLYMORPHISM AND DIAGNOSED MIGRAINE

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dc.authoridGürkan, Hakan/0000-0002-8967-6124
dc.authorwosidGürkan, Hakan/AAF-2866-2020
dc.contributor.authorGuler, S.
dc.contributor.authorGurkan, H.
dc.contributor.authorTozkir, H.
dc.contributor.authorTuran, N.
dc.contributor.authorCelik, Y.
dc.date.accessioned2024-06-12T11:08:33Z
dc.date.available2024-06-12T11:08:33Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated the phenotype-genotype association of the following endothelial nitric oxide synthase (eNOS) gene polymorphisms, rs743506, rs2070744, rs1799983, rs180079, rs3918226, rs207468799 and rs148554851, in patients suffering from migraine living in Edirne, Turkey. A total of 175 individuals, who had been diagnosed with migraine between April 2013 and December 2013, at the Neurology Department, Trakya University Medical Faculty, Edirne, Turkey, and 125 healthy controls were recruited. The above gene polymorphisms were analyzed from genomic DNA in both patient and control groups, using the pyro-sequencing method. The eNOS rs1799983 TT genotype frequency in migraine patients who had a headache duration of longer than 24 hours was statistically significantly higher than in patients who had migraine attacks that lasted under 24 hours (p = 0.047). In terms of the AGGTGGA haplotype, the severity of headache was statistically significant, and was found to be severe in 61.0% (p = 0.0001). Also in terms of the AGGTGGA haplotype, the duration of headache was statistically significant, and was >24 hours in 56.0% of patients (p = 0.008). In our study, there was no significant genotypephenotype relationship between eNOS rs743506, rs2070744, rs1799983, rs180079, rs3918226, rs207468799 and rs148554851 gene polymorphisms and migraine patients with and without aura living in Edirne, Turkey. The AGGTGGA haplotype constitutes a risk in terms of the severity and the duration of headaches in patients with migraine. This risk is significantly higher in patients with migraine with aura than patients with migraine without aura.en_US
dc.identifier.doi10.2478/bjmg-2014-0074
dc.identifier.endpage59en_US
dc.identifier.issn1311-0160
dc.identifier.issue2en_US
dc.identifier.pmid25937798en_US
dc.identifier.scopus2-s2.0-84928479564en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage49en_US
dc.identifier.urihttps://doi.org/10.2478/bjmg-2014-0074
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22479
dc.identifier.volume17en_US
dc.identifier.wosWOS:000352978700006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMacedonian Acad Sciences Artsen_US
dc.relation.ispartofBalkan Journal Of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMigraineen_US
dc.subjectAuraen_US
dc.subjectClinical Featuresen_US
dc.subjectEndothelial Nitric Oxide Synthase (Enos) Geneen_US
dc.subjectPolymorphismsen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectGlu298asp Polymorphismen_US
dc.subjectHeadacheen_US
dc.subjectAssociationen_US
dc.subjectHaplotypesen_US
dc.subjectNoen_US
dc.subjectSusceptibilityen_US
dc.subjectDysfunctionen_US
dc.subjectAuraen_US
dc.titleAN INVESTIGATION OF THE RELATIONSHIP BETWEEN THE eNOS GENE POLYMORPHISM AND DIAGNOSED MIGRAINEen_US
dc.typeArticleen_US

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