Screening of Glucose-6-Phosphate Dehydrogenase Deficiency in Cord Blood

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dc.authorwosidKaral, Yasemin/A-6622-2018
dc.contributor.authorAcipayam, Can
dc.contributor.authorOrhaner, Betul Biner
dc.contributor.authorKaral, Yasemin
dc.date.accessioned2024-06-12T11:02:43Z
dc.date.available2024-06-12T11:02:43Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: Glucose-6-phosphate dehydrogenase deficiency is an important factor in etiology of pathologic neonatal jaundice. The aim of this study was to indicate the significance of screening glucose-6-phosphate dehydrogenase deficiency in the cord blood of neonates and the frequency of this deficiency in the etiology of neonatal hyperbilirubinemia. Material and Method: The study was performed consecutive 1015 neonates were included. Five hundred fifty six (54.8%) of them were male and 459 (45.2%) were female. The following parameters were recorded: Gender, birth weight, birth height, head circumference and gestational age. The glucose-6-phosphate dehydrogenase level of neonates were measured with quantitative method in cord blood. Also, hemoglobine, hematocrite, red blood cell count and blood group were measured. The following parameters were recorded in cases with jaundice: exchange transfusion, phototherapy, physiologic and pathologic jaundice, peak bilirubin day, maximum bilirubin level, total bilirubin level at the first day of jaundice, beginning time of jaundice. Results: Enzyme deficiency was detected in 133 (13.1%) of neonates and 76 (57%1 of them were male, 57 (43%)were female. Significant difference was detected in low glucose-6-phosphate dehydrogenase enzyme level with jaundice group for total bilirubin level at the first day of jaundice, maximum total bilirubin level and pathologic jaundice (p<0.05). Discussion: The ratio of glucose-6-phosphate dehydrogenase deficiency was found in Edirne in this study and this ratio was higher than other studies conducted in our country. For this reason, glucose-6-phosphate dehydrogenase enzyme level in cord blood of neonates should be measured routinely and high risk neonates should be followed up for hyperbilirubinemia and parents should be informed in our region.en_US
dc.identifier.doi10.4328/JCAM.2390
dc.identifier.endpage8en_US
dc.identifier.issn1309-0720
dc.identifier.issn1309-2014
dc.identifier.startpage4en_US
dc.identifier.urihttps://doi.org/10.4328/JCAM.2390
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21388
dc.identifier.volume5en_US
dc.identifier.wosWOS:000215574200002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherDerman Medical Publen_US
dc.relation.ispartofJournal Of Clinical And Analytical Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlucose-6-Phosphate Dehydrogenaseen_US
dc.subjectNeonateen_US
dc.subjectJaundiceen_US
dc.titleScreening of Glucose-6-Phosphate Dehydrogenase Deficiency in Cord Blooden_US
dc.typeArticleen_US

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