The prevalence of hereditary thrombophilia in the Trakya region of Turkey

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dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridDEMIR, Mehmet/0000-0001-5942-3751
dc.authorwosidSunar, Hasan/A-8685-2018
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidDEMIR, Mehmet/AAH-2121-2019
dc.contributor.authorDemir, M
dc.contributor.authorVural, Ö
dc.contributor.authorSunar, H
dc.contributor.authorAltun, A
dc.contributor.authorYorulmaz, F
dc.contributor.authorÖzbay, G
dc.date.accessioned2024-06-12T11:17:03Z
dc.date.available2024-06-12T11:17:03Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe prevalences of deficiencies in antithrombin III (AT III), protein C (PC), protein S (PS) and in the activated protein C (APC) resistance in the thrombotic population of the Trakya region, Turkey were investigated. 37 patients with venous thrombosis (VT) and 17 patients with arterial thrombosis (ArT) were included in this study. The mean ages of the patients with VT and ArT were 46 years (range 20-70) and 38 years (range 32-40), respectively; The activity of AT III was measured by commercially available immuno-turbidimetric assay. The activities of PC and PS were determined by coagulometric assay. The APC resistance was measured using a modified APTT-based clotting assay. Among the VT patients, there were 2 cases (5.4%) with AT Ill, 5 (13.51%) with PC deficiency, 5 (13.51%) with PS deficiency and 2 (5.4%) with APC resistance. In the ArT patient group, there was 1 patient (5.88%) with AT III, 3 (17.64%) with PC deficiency, 1 (5.88%) with PS deficiency and no APC resistant patients, while there was one (2.08%) with PC deficiency and one (2.08%) with APC resistance in the control group (49 persons, mean age 41 years). The relative risk of thrombosis (odds ratio) was 1.7 in the deficiency of PC and 5.6 in the deficiency of PS. The data presented suggests that the prevalences of AT III, PC and PS deficiencies causing thrombophilia in the Trakya region of Turkey are higher than in other reported studies while the APC resistance is lower than in others. Further studies including more patients would be required to clarify these discrepancies.en_US
dc.identifier.doi10.3349/ymj.2000.41.4.436
dc.identifier.endpage440en_US
dc.identifier.issn0513-5796
dc.identifier.issue4en_US
dc.identifier.pmid10992803en_US
dc.identifier.scopus2-s2.0-0034242333en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage436en_US
dc.identifier.urihttps://doi.org/10.3349/ymj.2000.41.4.436
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24564
dc.identifier.volume41en_US
dc.identifier.wosWOS:000089183400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherYonsei Univ College Medicineen_US
dc.relation.ispartofYonsei Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVenous Thrombosisen_US
dc.subjectArterial Thrombosisen_US
dc.subjectNatural Inhibitorsen_US
dc.subjectActivated Protein C Resistanceen_US
dc.subjectTurkish Populationen_US
dc.subjectActivated Protein-Cen_US
dc.subjectFactor-V-Leidenen_US
dc.subjectVenous Thrombosisen_US
dc.subjectMyocardial-Infarctionen_US
dc.subjectAntithrombin-Iiien_US
dc.subjectDeficiencyen_US
dc.subjectResistanceen_US
dc.subjectStrokeen_US
dc.subjectRisken_US
dc.subjectThromboembolismen_US
dc.titleThe prevalence of hereditary thrombophilia in the Trakya region of Turkeyen_US
dc.typeArticleen_US

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