Investigation on effects of walnut essential oil against glutamate toxicity on cortex neuron and LN405 cancer cell lines, diabetes, and some microorganisms

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dc.authoridGoger, Gamze/0000-0003-2978-5385
dc.authoridDemirci, Betul/0000-0003-2343-746X
dc.authorwosidGoger, Gamze/JCE-6911-2023
dc.authorwosidHacimuftuoglu, Ahmet/U-9109-2018
dc.authorwosidDemirci, Betul/AHA-2298-2022
dc.contributor.authorYesilyurt, Fatma
dc.contributor.authorYuca, Hafize
dc.contributor.authorKarakaya, Songul
dc.contributor.authorTekman, Enes
dc.contributor.authorDemirci, Betul
dc.contributor.authorTaghizadehghalehjoughi, Ali
dc.contributor.authorGoger, Gamze
dc.date.accessioned2024-06-12T11:17:12Z
dc.date.available2024-06-12T11:17:12Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, leaf essential oil effects on glutamate toxicity model formed in cortex neurons and LN405 cell cultures were investigated. Antidiabetic activity was evaluated by & alpha;-amylase and & alpha;-glucosidase inhibitions. MIC was used for antimicrobial activity. Seven groups were examined with MTT. Glutamate 10-5 mM in cortex showed 62% viability whereas oil viability did not increase in a dose-dependent manner and the highest viability rate was observed. There are four types of glandular trichomes in leaf anatomy of walnut. The oil exhibited half as much & alpha;-glucosidase inhibitory activity with an IC50 value of 8105 & mu;g/mL, compared to positive control acarbose (IC50 = 4762 & mu;g/mL). MIC of oil was determined to be 625 & mu;g/mL against E. coli, C. albicans, and C. parapsilosis, whereas S. aureus exhibited a MIC of 1250 & mu;g/mL. Major compounds of oil were found as & beta;-pinene (17.6%), & alpha;-pinene (11.3%), & beta;-eudesmol (8.6%), and caryophyllene oxide (6.2%).en_US
dc.identifier.doi10.1080/10412905.2023.2234372
dc.identifier.endpage381en_US
dc.identifier.issn1041-2905
dc.identifier.issn2163-8152
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85164718552en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage372en_US
dc.identifier.urihttps://doi.org/10.1080/10412905.2023.2234372
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24602
dc.identifier.volume35en_US
dc.identifier.wosWOS:001022771900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Essential Oil Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectWalnuten_US
dc.subjectJuglans Regiaen_US
dc.subjectLN405en_US
dc.subjectGlutamateen_US
dc.subjectAntidiabeticen_US
dc.subjectAntimicrobialen_US
dc.subject>en_US
dc.subjectJuglans-Regia L.en_US
dc.subjectVolatile Oilen_US
dc.subjectAntioxidanten_US
dc.subjectLeavesen_US
dc.subjectNigraen_US
dc.titleInvestigation on effects of walnut essential oil against glutamate toxicity on cortex neuron and LN405 cancer cell lines, diabetes, and some microorganismsen_US
dc.typeArticleen_US

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