The histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicity

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorCaloglu, Murat
dc.contributor.authorCaloglu, Vuslat Yurut
dc.contributor.authorYalta, Tulin
dc.contributor.authorYalcin, Omer
dc.contributor.authorUzal, Cem
dc.date.accessioned2024-06-12T10:50:38Z
dc.date.available2024-06-12T10:50:38Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The aim of the study was to compare the protective efficacy of l-carnitine (LC) to amifostine on radiation-induced acute small intestine damage. Materials and Methods: Thirty, 4-week-old Wistar albino rats were randomly assigned to four groups - Group 1: control (CONT, n = 6), Group 2: irradiation alone (RT, n = 8), Group 3: amifostine plus irradiation (AMIRT, n = 8), and Group 4: l-Carnitine plus irradiation (LCRT, n = 8). The rats in all groups were irradiated individually with a single dose of 20 Gy to the total abdomen, except those in CONT. LC (300 mg/kg) or amifostine (200 mg/kg) was used 30 min before irradiation. Histopathological analysis of small intestine was carried out after euthanasia. Results: Pretreatment with amifostine reduced the radiation-induced acute degenerative damage (P = 0.009) compared to the RT group. Pretreatment with LC did not obtain any significant difference compared to the RT group. The vascular damage significantly reduced in both of the AMIRT (P = 0.003) and LCRT group (P = 0.029) compared to the RT group. The overall damage score was significantly lower in the AMIRT group than the RT group (P = 0.009). There was not any significant difference between the LCRT and RT group. Conclusions: Amifostine has a marked radioprotective effect against all histopathological changes on small intestinal tissue while LC has limited effects which are mainly on vascular structure.en_US
dc.identifier.doi10.4103/0973-1482.98982
dc.identifier.endpage265en_US
dc.identifier.issn0973-1482
dc.identifier.issue2en_US
dc.identifier.pmid22842372en_US
dc.identifier.scopus2-s2.0-84864716392en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage260en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.98982
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18073
dc.identifier.volume8en_US
dc.identifier.wosWOS:000307115000016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publicationsen_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Toxicityen_US
dc.subjectAmifostineen_US
dc.subjectIrradiationen_US
dc.subjectL-Carnitineen_US
dc.subjectRadioprotectionen_US
dc.subjectSmall Intestineen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectOxidative Stressen_US
dc.subjectIonizing-Radiationen_US
dc.subjectReperfusion Injuryen_US
dc.subjectRat Modelen_US
dc.subjectWr-2721en_US
dc.subjectRadiotherapyen_US
dc.subjectIrradiationen_US
dc.subjectRadioprotectionen_US
dc.subjectPreventionen_US
dc.titleThe histopathological comparison of L-carnitine with amifostine for protective efficacy on radiation-induced acute small intestinal toxicityen_US
dc.typeArticleen_US

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