Analysis of Antenatal Sonographic Features of the Fetuses with Trisomy 21

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dc.authoridSAYIN, Cenk/0000-0001-7286-472X
dc.authorwosidSAYIN, Cenk/AAC-5802-2019
dc.contributor.authorUzun, Isil
dc.contributor.authorSayin, Cenk
dc.contributor.authorErzincan, Selen
dc.contributor.authorIvan, Cihan
dc.contributor.authorSutcu, Havva
dc.contributor.authorVarol, Fusun
dc.date.accessioned2024-06-12T10:59:48Z
dc.date.available2024-06-12T10:59:48Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: To evaluate the second trimester ultrasound findings of the fetuses with Down syndrome. Patients and Methods: We conducted a retrospective analysis of 781 patients who underwent prenatal invasive test between November 2011 and July 2015. Based on the patients' medical records, the demographic data and second trimester ultrasound findings of the fetuses with Down syndrome were retrospectively analyzed. Results: Trisomy 21 was detected in 26 (3.3%) patients. The median (min-max) maternal age of trisomy 21 cases was 31.9 (17 - 41) years. The karyotype indications were high risk in the combined test, triple test, quadruple test and pathologic findings on the ultrasound examination. One case in the ultrasound group had both of combined test and triple test in the low risk area. In this patient, ultrasound examination revealed talipes equinovarus and delayed chorioamniotic fusion at 27 weeks of gestation. Trisomy 21 was detected in four patients by chorion villus biopsy at the first trimester. Second trimester ultrasound was performed in 22 out of these 26 women. However, there were sonographic findings in only 16 (72.7%) patients. Six (27.2%) fetuses had no minor or major anomaly at the detailed ultrasound examination. The frequency of major cardiac anomaly was 22.7%. Choroid plexus cyst and aberrant right subclavian artery were the single findings in two fetuses at the second trimester ultrasound exam. Conclusion: Although the sensitivity of second trimester genetic ultrasound for detection of fetal Down syndrome at our perinatology unit was rather high, nearly one of three patients with Down syndrome had no detectable sonographic finding. Second trimester ultrasound alone is not strong enough to exclude the diagnosis of Down's syndromeen_US
dc.identifier.doi10.5812/iranjradiol.62473
dc.identifier.issn1735-1065
dc.identifier.issn2008-2711
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85048730802en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.urihttps://doi.org/10.5812/iranjradiol.62473
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20582
dc.identifier.volume15en_US
dc.identifier.wosWOS:000435801600021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofIranian Journal Of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDown Syndromeen_US
dc.subjectSonographyen_US
dc.subjectScreenningen_US
dc.subjectDown-Syndromeen_US
dc.subjectChromosomal-Abnormalitiesen_US
dc.subject2nd-Trimesteren_US
dc.subjectMetaanalysisen_US
dc.subjectMarkersen_US
dc.subjectUltrasounden_US
dc.subjectChorionen_US
dc.subjectAmnionen_US
dc.subjectRisken_US
dc.titleAnalysis of Antenatal Sonographic Features of the Fetuses with Trisomy 21en_US
dc.typeArticleen_US

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