Low Levels of Protein Z Are Associated With HELLP Syndrome and its Severity

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dc.authoridugurel, vedat/0000-0002-1307-4688
dc.contributor.authorKaygusuz, Isik
dc.contributor.authorFiratli-Tuglular, Tulin
dc.contributor.authorToptas, Tayfur
dc.contributor.authorUgurel, Vedat
dc.contributor.authorDemir, Muzaffer
dc.date.accessioned2024-06-12T11:13:04Z
dc.date.available2024-06-12T11:13:04Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractProtein Z (PZ) was found to be associated with pregnancy complications. There are no data implying an association between hemolysis (H), elevated liver enzymes (EL), and low platelet counts (LP) (HELLP) syndrome and changes in plasma levels of PZ. The aim of this study is to investigate whether HELLP syndrome is associated with plasma concentrations of PZ. Protein Z levels in 29 women with HELLP syndrome were compared with 29 healthy, nulliparous and 25 normal pregnant women. The median PZ levels in patients with HELLP syndrome were found to be significantly lower than those of pregnant women. No significant difference was found between HELLP and healthy groups. Protein Z levels correlated with platelet counts, lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) levels in patients with HELLP syndrome. Median PZ level was higher in partial HELLP than in complete HELLP. We calculated 1330 ng/mL as a cutoff value for PZ level to discriminate HELLP syndrome from normal pregnancy. Low PZ levels are associated with the pathobiology of HELLP syndrome.en_US
dc.identifier.doi10.1177/1076029609357738
dc.identifier.endpage219en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue2en_US
dc.identifier.pmid20460354en_US
dc.identifier.scopus2-s2.0-79952810005en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage214en_US
dc.identifier.urihttps://doi.org/10.1177/1076029609357738
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23390
dc.identifier.volume17en_US
dc.identifier.wosWOS:000288463500014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectProtein Zen_US
dc.subjectHELLP Syndromeen_US
dc.subjectPregnancyen_US
dc.subjectConsumptive Coagulopathyen_US
dc.subjectPreeclampsiaen_US
dc.subjectFetal Demiseen_US
dc.subjectPregnancyen_US
dc.subjectPreeclampsiaen_US
dc.subjectThrombosisen_US
dc.subjectRisken_US
dc.subjectVeinen_US
dc.titleLow Levels of Protein Z Are Associated With HELLP Syndrome and its Severityen_US
dc.typeArticleen_US

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