Clinical Significance of Abnormal Results of Second Trimester Hormones in the Absence of Aneuploidy

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dc.contributor.authorUzun, Isil
dc.contributor.authorSayin, N. Cenk
dc.contributor.authorInan, Cihan
dc.contributor.authorErzincan, Selen
dc.contributor.authorSutcu, Havva
dc.contributor.authorVarol, Fusun
dc.date.accessioned2024-06-12T10:51:41Z
dc.date.available2024-06-12T10:51:41Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Abnormal levels of hormones during the second trimester of pregnancy may predict genetic disorders and complications of pregnancy. Objectives: This study was performed to evaluate the clinical significance of abnormal results in second-trimester markers in the absence of aneuploidy. Methods: This case-control study was conducted between May 2014 and December 2015 in the maternal-fetal unit, Trakya University Faculty of Medicine in Turkey. Overall, 108 Turkish pregnant females were included in this study. This research recruited patients (n = 46) with normal karyotype, who underwent invasive prenatal tests because of abnormal levels of second-trimester hormones, along with a cohort of controls (n = 31) with hormonal results within normal ranges. For each patient, the researchers recorded the mode of delivery, gestational age at delivery, birth weight, complications, and adverse outcome of the pregnancy. Data were analyzed using Fisher's exact tests and Yates continuity correction tests for qualitative variables, and t- test and Mann-Whitney U test for quantitative variables. Results: Maternal age (mean +/- SD) of the entire group was 31.77 +/- 5.68 years (study group: 31.23 +/- 4.39; controls: 32.13 +/- 6.43, P > 0.05). Preterm delivery and preeclampsia were significantly higher in the study group (P = 0.02). In the study group, Alpha Fetoprotein (AFP) levels were significantly higher in patients with preeclampsia yet not in the controls. The AFP values under 0.77 multiple of the median in patients with elevated test results in the absence of aneuploidy appeared to be associated with the development of preeclampsia later in pregnancy. Conclusions: Although the significance of higher AFP values have been discussed in the literature in terms of the development of adverse outcomes, the present study suggests that lower values must also be taken into account during patient follow-up.en_US
dc.identifier.doi10.5812/ircmj.64310
dc.identifier.issn2074-1804
dc.identifier.issn2074-1812
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85051377255en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.5812/ircmj.64310
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18451
dc.identifier.volume20en_US
dc.identifier.wosWOS:000444717000009en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKowsar Publen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAneuploidyen_US
dc.subjectDisordersen_US
dc.subjectGeneticen_US
dc.subjectHormoneen_US
dc.subjectPreeclampsiaen_US
dc.subjectPregnancyen_US
dc.subjectSerum Alpha-Fetoproteinen_US
dc.subjectAdverse Pregnancy Outcomesen_US
dc.subjectBiochemical Markersen_US
dc.subjectDown-Syndromeen_US
dc.subject2nd-Trimesteren_US
dc.subject1st-Trimesteren_US
dc.subjectComplicationsen_US
dc.subjectAssociationen_US
dc.titleClinical Significance of Abnormal Results of Second Trimester Hormones in the Absence of Aneuploidyen_US
dc.typeArticleen_US

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