Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats

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dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridÇavuşoğlu, Türker/0000-0001-7100-7080
dc.authoridGÜRGÜL, Serkan/0000-0002-1450-490X
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoridUyanikgil, Yigit/0000-0002-4016-0522
dc.authoriderten, nilgun/0000-0002-9277-2870
dc.authorwosidUyanikgil, Yigit/KIE-9628-2024
dc.authorwosidÇavuşoğlu, Türker/AAJ-9609-2020
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.authorwosidbalcioglu, huseyin avni/AAE-4687-2019
dc.authorwosidbalcioglu, h.a./AAB-8354-2020
dc.authorwosidGÜRGÜL, Serkan/AAC-2995-2020
dc.authorwosidUyanikgil, Yigit/M-2746-2019
dc.contributor.authorUyanikgil, Yigit
dc.contributor.authorCavusoglu, Turker
dc.contributor.authorBalcioglu, Huseyin A.
dc.contributor.authorGurgul, Serkan
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorOzlece, Hatice K.
dc.contributor.authorErten, Nilgun
dc.date.accessioned2024-06-12T11:00:11Z
dc.date.available2024-06-12T11:00:11Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe safety of patients with epilepsy consuming sweetening agents, which is becoming increasingly prevalent for various reasons, is a topic that should be emphasized as sensitively as it is for other diseases. Patients with epilepsy consume sweetening agents for different reasons such being diabetic or overweight. They can occasionally be exposed to sweetening agents unrestrainedly through consuming convenience food, primarily beverages. This study aimed to investigate the effects of rebaudioside A (Reb-A), which is a steviol glycoside produced from the herb Stevia rebaudiana (Bertoni), on epileptic seizures and convulsions induced by pentylenetetrazole (PTZ). Forty-eight male rats were used. Twenty-four rats were administered 35 mg/kg PTZ to trigger epileptiform activity; the remaining 24 rats were administered 70 mg/kg PTZ to trigger the convulsion model. The epileptiform activity was evaluated by spike percentage, whereas convulsion was evaluated by Racine's Convulsion Scale and the onset time of the first myoclonic jerk. Statistical analysis revealed a statistically significant decrease in the Racine's Convulsion Scale score and increase in the latency of first myoclonic jerk in a dose-dependent manner for the rat groups in which PTZ epilepsy had been induced and Reb-A had been administered. For the groups that were administered Reb-A, the spike decrease was apparent in a dose-dependent manner, based on the spike percentage calculation. These results indicated that Reb-A has positive effects on PTZ-induced convulsions. Copyright (C) 2016, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.en_US
dc.identifier.doi10.1016/j.kjms.2016.07.002
dc.identifier.endpage451en_US
dc.identifier.issn1607-551X
dc.identifier.issue9en_US
dc.identifier.pmid27638403en_US
dc.identifier.scopus2-s2.0-84995544901en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage446en_US
dc.identifier.urihttps://doi.org/10.1016/j.kjms.2016.07.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20736
dc.identifier.volume32en_US
dc.identifier.wosWOS:000384018800002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Taiwanen_US
dc.relation.ispartofKaohsiung Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectroencephalogramen_US
dc.subjectExperimental Epilepsy Modelen_US
dc.subjectPentylenetetrazolen_US
dc.subjectRebaudioside Aen_US
dc.subjectStevia-Rebaudiana Bertonien_US
dc.subjectAntiepileptic Drugsen_US
dc.subjectSteviosideen_US
dc.subjectEpilepsyen_US
dc.subjectSweeteneren_US
dc.subjectAspartameen_US
dc.subjectGlycosideen_US
dc.subjectSeizureen_US
dc.subjectSafetyen_US
dc.subjectMenen_US
dc.titleRebaudioside A inhibits pentylenetetrazol-induced convulsions in ratsen_US
dc.typeArticleen_US

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