Staphylococcus Aureus Enterotoxin A and Enterotoxin B Specific IgE Antibodies in Atopic Dermatitis

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dc.authoridYıldırım, Sema/0000-0001-7311-519X
dc.authorwosidYıldırım, Sema/GQA-9215-2022
dc.contributor.authorYildirim, Sema
dc.contributor.authorYazicioglu, Mehtap
dc.contributor.authorCiftci, Sukran
dc.date.accessioned2024-06-12T10:52:48Z
dc.date.available2024-06-12T10:52:48Z
dc.date.issued2024
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: A correlation between the intensity of S. aureus colonization and skin inflammation has been demonstrated. 30-60% of S. aureus bacteria in patients with atopic dermatitis (AD) generate exotoxins, specifically superantigen-like enterotoxins A-B-C-D and toxic shock syndrome toxin-1. This study aimed to determine the role of serum staphylococcal enterotoxin A (SEA) and staphylococcal enterotoxin B (SEB)-specific IgE antibodies in children with AD. Materials and Methods: Forty-four children with AD, 30 with allergic respiratory disease (ARD) without AD, and 25 nonatopic healthy children were included in this study. AD cases were diagnosed according to Hanifin and Rajka criteria. The severity of AD was evaluated by the Eczema Area and Severity Index. Serum total IgE (tIgE), SEA-specific IgE and SEB-specific IgE levels were analyzed in all children.Results: Serum tIgE levels were significantly elevated in children with ARD without AD compared to children with AD and healthy children (p=0.041). However, there was no significant difference in the levels and the rates of positive SEA-specific IgE and SEB-specific IgE for children with AD, children with ARD without AD, and healthy children. A significantly positive correlation was detected between the EASI scores and SEA-IgE levels in children with AD (p=0.002). Conclusion: Although the role of SEA in the pathogenesis of AD through IgE-mediated mechanisms is not fully known, the data in our study seems to provide support to the role of SEA on the severity of AD. To conclude, adding antistaphylococcal treatment to anti-inflammatory therapy may be helpful in obtaining an effective clinical response in children with moderate to severe AD.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Committee (BAPKO) [686]en_US
dc.description.sponsorshipThis study was supported by a grant obtained from Trakya University Scientific Research Projects Committee (BAPKO Project No:686)en_US
dc.identifier.doi10.21911/aai.2023.423
dc.identifier.endpage40en_US
dc.identifier.issn1308-9234
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85191262647en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://doi.org/10.21911/aai.2023.423
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18838
dc.identifier.volume22en_US
dc.identifier.wosWOS:001147144400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Natl Soc Allergy And Clinical Immunologyen_US
dc.relation.ispartofAsthma Allergy Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtopic Dermatitisen_US
dc.subjectSeverity Of Atopic Dermatitisen_US
dc.subjectStaphylococcus Aureus Enterotoxin Aen_US
dc.subjectStaphylococcus Aureus Enterotoxin Ben_US
dc.subjectColonizationen_US
dc.subjectSuperantigensen_US
dc.subjectInfectionsen_US
dc.subjectManagementen_US
dc.subjectExotoxinsen_US
dc.subjectBacterialen_US
dc.subjectFeaturesen_US
dc.subjectChildrenen_US
dc.titleStaphylococcus Aureus Enterotoxin A and Enterotoxin B Specific IgE Antibodies in Atopic Dermatitisen_US
dc.typeArticleen_US

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