Protective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxide

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorErbas, Hakan
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorUsta, Ufuk
dc.contributor.authorErten, Oya
dc.date.accessioned2024-06-12T10:52:29Z
dc.date.available2024-06-12T10:52:29Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBreast cancer remains one of the most common types of cancer. High levels of arginase and ornithine in different carcinomas may indicate their relation to cancer. Carnitine is a cofactor required for the transformation of free long-chain fatty acids into acetyl-carnitines. We have examined the protective effect of carnitine and the possibility that it disturbs arginase-nitric oxide (NO) interaction. Histopathological examination, arginase activity, ornithine and NO levels were determined in tumour tissues. Mitotic cells significantly decreased in the treatment group. Tissue arginase activity and ornithine levels decreased significantly with carnitine. NO levels were significantly higher in the treatment group. One of the possible mechanisms of carnitine's protective role in tumour progression might be its promotion of NO. This mechanism could decrease the production of tumour-promoting agents, polyamines, and increase the production of NO, thereby exerting a protective effect on cancer development. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.cellbi.2007.06.007
dc.identifier.endpage1419en_US
dc.identifier.issn1065-6995
dc.identifier.issn1095-8355
dc.identifier.issue11en_US
dc.identifier.pmid17689108en_US
dc.identifier.scopus2-s2.0-34548435964en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1414en_US
dc.identifier.urihttps://doi.org/10.1016/j.cellbi.2007.06.007
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18718
dc.identifier.volume31en_US
dc.identifier.wosWOS:000249610600018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArginaseen_US
dc.subjectBreast Canceren_US
dc.subjectCarnitineen_US
dc.subjectMiceen_US
dc.subjectNitric Oxide (NO)en_US
dc.subjectOrnithineen_US
dc.subjectIn-Vivoen_US
dc.subjectMetabolismen_US
dc.subjectTumoren_US
dc.subjectSerumen_US
dc.subjectTissueen_US
dc.subjectPathophysiologyen_US
dc.subjectPolyaminesen_US
dc.subjectCarcinomaen_US
dc.subjectApoptosisen_US
dc.subjectMarkeren_US
dc.titleProtective role of carnitine in breast cancer via decreasing arginase activity and increasing nitric oxideen_US
dc.typeArticleen_US

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