Maternal serum levels of tumor necrosis factor-? and interleukin-2 receptor in threatened abortion

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorGücer, F
dc.contributor.authorBalkanli-Kaplan, P
dc.contributor.authorYüksel, M
dc.contributor.authorSayin, NC
dc.contributor.authorYüce, MA
dc.contributor.authorYardim, T
dc.date.accessioned2024-06-12T11:16:27Z
dc.date.available2024-06-12T11:16:27Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: We evaluated tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 (IL-2) receptor levels in patients with threatened abortion and compared the levels with normal and pathologic pregnancies. Design: A prospective, nonrandomized, case-control study. Setting: Academic research setting. Patient(s): Twenty-two patients with threatened abortion, 18 patients with pathologic pregnancies, 20 healthy pregnant women, and 20 nonpregnant women. Intervention (s): Maternal serum TNF-alpha and IL-2 receptor levels were measured with a solid-phase, two-site chemiluminescent enzyme immunometric assay method. Main Outcome Measure(s): TNF-alpha and IL-2 receptor levels. Result(s): The mean SEM maternal serum IL-2 receptor level for patients with threatened abortion was 481.3 +/- 35.7 U/mL, compared with 426.5 +/- 22.4 U/mL in the normal pregnant group. There was no statistically significant difference in the mean SEM serum TNF-alpha level between the patients with threatened abortion and those with normal pregnancies (16.1 +/- 2.7 pg/mL vs. 10.9 +/- 0.8 pg/mL). The mean SEM maternal serum IL-2 receptor level was significantly higher in patients with pathologic pregnancies than in those with normal pregnancies (506.2 +/- 27.6 U/mL vs. 426.5 22.4 U/mL). The mean SEM maternal serum TNF-alpha level was significantly higher in patients with pathologic pregnancies than in those with threatened abortion (39.2 +/- 9.5 pg/mL vs. 16.1 +/- 2.7 pg/mL) and normal pregnancies (39.2 +/- 9.5 pg/mL vs. 10.9 +/- 0.8 pg/mL). Conclusion(s): In comparison with normal pregnancies, maternal serum IL-2 receptor and TNF-alpha levels were not significantly increased in patients with threatened abortion with good outcome. (Fertil Steril(R) 2001;76: 707-11. (C) 2001 by American Society for Reproductive Medicine.).en_US
dc.identifier.doi10.1016/S0015-0282(01)02002-7
dc.identifier.endpage711en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue4en_US
dc.identifier.pmid11591402en_US
dc.identifier.scopus2-s2.0-0034803867en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage707en_US
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(01)02002-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24323
dc.identifier.volume76en_US
dc.identifier.wosWOS:000171511600010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTNF-Alphaen_US
dc.subjectIL-2 Receptoren_US
dc.subjectThreatened Abortionen_US
dc.subjectMissed Abortionen_US
dc.subjectT-Cell Determinationen_US
dc.subjectX Dba/2 Miceen_US
dc.subjectTnf-Alphaen_US
dc.subjectCytokinesen_US
dc.subjectLymphocytesen_US
dc.subjectWomenen_US
dc.subjectTh1en_US
dc.titleMaternal serum levels of tumor necrosis factor-? and interleukin-2 receptor in threatened abortionen_US
dc.typeArticleen_US

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