Differential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinoma

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dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidTamer, Lulufer/AAG-5796-2021
dc.authorwosidYildirim, Hatice/O-7121-2016
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorAyaz, Lokman
dc.contributor.authorGorur, Aysegul
dc.contributor.authorYaroglu, Hatice Yildirim
dc.contributor.authorOzcan, Cengiz
dc.contributor.authorTamer, Lulufer
dc.date.accessioned2024-06-12T10:56:33Z
dc.date.available2024-06-12T10:56:33Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAltered microRNA (miRNA) expression has been found in many cancers, including lung, breast, prostate, bladder and colorectal cancer. Many recent studies have demonstrated that aberrant plasma miRNAs were also found in various types of cancers. However, the alteration in plasma miRNA expressions in laryngeal squamous cell carcinoma (LSCC) remains unclear. The present study aimed to investigate the alterations in plasma miRNAs in LSCC. In the present study, the expression profiles of 738 miRNAs in plasma from 20 patients and 44 healthy subjects were evaluated using high-throughput real-time quantitative polymerase chain reaction. Our results demonstrated that expression levels of 17 miRNAs were significantly upregulated in patients with LSCCs when compared to control group (p < 0.05). Expression levels of nine miRNAs were found significantly downregulated in LSCC patients (p < 0.05). In addition, 17 miRNAs were expressed only in LSCC group, and five of these miRNAs (miR-331-3p, 603, 1303, 660-5p and 212-3p) are LSCC specific and never seen before in plasma of any human subject. In conclusion, our study suggests that detecting these LSCC-specific miRNAs in plasma might serve as novel noninvasive biomarkers for LSCC.en_US
dc.description.sponsorshipCukurova Development Agency (CKA), Mersin, Turkey [TR62-09-03]en_US
dc.description.sponsorshipThis study, which is the part of Establishment of molecular substructure laboratory for early diagnosis of cancer (TR62-09-03) project was supported by grants from Cukurova Development Agency (CKA), Mersin, Turkey.en_US
dc.identifier.doi10.1007/s00432-013-1469-2
dc.identifier.endpage1506en_US
dc.identifier.issn0171-5216
dc.identifier.issn1432-1335
dc.identifier.issue9en_US
dc.identifier.pmid23817697en_US
dc.identifier.scopus2-s2.0-84882571070en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1499en_US
dc.identifier.urihttps://doi.org/10.1007/s00432-013-1469-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19833
dc.identifier.volume139en_US
dc.identifier.wosWOS:000323250700008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Cancer Research And Clinical Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCirculating Mirnaen_US
dc.subjectLaryngeal Squamous Cell Carcinomaen_US
dc.subjectRT-PCRen_US
dc.subjectLarynxen_US
dc.subjectDiagnosticen_US
dc.subjectCirculating Micrornasen_US
dc.subjectDown-Regulationen_US
dc.subjectCanceren_US
dc.subjectBiomarkersen_US
dc.subjectSerumen_US
dc.subjectProliferationen_US
dc.subjectDiagnosisen_US
dc.subjectHeaden_US
dc.subjectRnaen_US
dc.titleDifferential expression of microRNAs in plasma of patients with laryngeal squamous cell carcinoma: potential early-detection markers for laryngeal squamous cell carcinomaen_US
dc.typeArticleen_US

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