Comparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Rats

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dc.authoridOzen, Alaattin/0000-0001-9219-6001
dc.contributor.authorCakina, S.
dc.contributor.authorGulyasar, T.
dc.contributor.authorOzen, A.
dc.contributor.authorParlar, S.
dc.contributor.authorCukur, Z.
dc.contributor.authorKurkcu, N.
dc.contributor.authorUzal, C.
dc.date.accessioned2024-06-12T11:08:13Z
dc.date.available2024-06-12T11:08:13Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, we aimed to compare the protective effects of melatonin and amifostine on radiation-induced oxidative stress. Fifty female Wistar rats (3-4 months old, weighing 200 +/- 25 g) were divided into five groups (with ten rats each) and treated as follows: control (Cont), radiotherapy alone (RT), radiotherapy + amifostine (RT+A-MI), radiotherapy + melatonin (RT+MEL), radiotherapy + amifostine + melatonin (RT+AMI+MEL). Rats were irradiated individually with a single dose of 8 Gy and amifostine (200 mg/kg) and melatonin (10 mg/kg) was administered to rats 30 minutes before irradiation. At the end of this follow-up period (72 hours) the rats were sacrificed. Spectrophotometric Analysis has been performed to kidney tissue samples. As a result of statistical comparison between groups after RT, total antioxidant capacity (TAC) decreased, total oxidant status (TOS) and oxidative stress index (OSI) increased, although the statistically significant change was only for OSI (p = 0.030). Addition of AMI or MEL to RT increased TAC and OSI significantly (p = 0.000), but there was no additive effect for TAC and OSI when both drugs were given together (p = 1.000, p = 0.172, respectively). In terms of TOS, statistically significant increasing was only for AMI (p = 0.000). There was protective effect when both drugs were given together against on Radiation-Induced Renal Oxidative Stress.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects Unit [TUBAP 2012/104]en_US
dc.description.sponsorshipThe authors thank to Trakya University Scientific Research Projects Unit for funding of this project in part (No. TUBAP 2012/104).en_US
dc.identifier.doi10.12681/jhvms.22948
dc.identifier.endpage2010en_US
dc.identifier.issn1792-2720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85085171574en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2005en_US
dc.identifier.urihttps://doi.org/10.12681/jhvms.22948
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22357
dc.identifier.volume71en_US
dc.identifier.wosWOS:000526941600010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherHellenic Veterinary Medical Socen_US
dc.relation.ispartofJournal Of The Hellenic Veterinary Medical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectAmifostineen_US
dc.subjectRadiation-Induced Renal Oxidative Stressen_US
dc.subjectRatsen_US
dc.subjectIonizing-Radiationen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectMechanismsen_US
dc.subjectToxicityen_US
dc.subjectDamageen_US
dc.titleComparison of Protective Effects of Melatonin and Amifostine on Radiation-Induced Renal Oxidative Stress in Ratsen_US
dc.typeArticleen_US

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