Expression and role of interleukin-23 in human endometrium throughout the menstrual cycle and early pregnancy

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dc.authoridUz, Yesim/0000-0002-0381-4590
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorMurk, William
dc.contributor.authorYetkin, Celal Emre
dc.contributor.authorKayisli, Umit Ali
dc.contributor.authorArici, Aydin
dc.date.accessioned2024-06-12T11:03:55Z
dc.date.available2024-06-12T11:03:55Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractInterleukin-23 (IL-23) is a novel cytokine involved in the regulation of organ-specific immune responses. We hypothesized that expression of IL-23 in the human endometrium is menstrual cycle and pregnancy dependent, and is involved in endometrial immune regulation. IL-23 expression and regulation was investigated in the human endometrium and placenta in vivo using immunohistochemistry and in vitro using Western blot and cell viability analyses. IL-23 immunoreactivity in endometrial glandular cells was highest in the late proliferative and early secretory phases, as compared to other cycle phases and first trimester tissues. Endometrial stromal cells (ESC) showed weak IL-23 immunoreactivity without significant changes in intensity and distribution throughout the menstrual cycle. First trimester decidual cells revealed significantly stronger IL-23 staining compared to ESC from non-pregnant endometrium. Both villous cytotrophoblasts and syncytiotrophoblasts also showed positive IL-23 immunoreactivity, with a higher staining in syncytiotrophoblasts. In the trophoblastic cell line HRT8, IL-23 expression increased in a time-dependent manner, but was undetectable in stromal cells under all treatment conditions. ESC treated with recombinant IL-23 showed significantly decreased IL-8 secretion and cell viability. These results suggest a possible regulatory role for IL-23 in the menstrual cycle and in early pregnancy, although the extent and function of this role are yet to be determined. (C) 2010 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.jri.2010.06.154
dc.identifier.endpage27en_US
dc.identifier.issn0165-0378
dc.identifier.issn1872-7603
dc.identifier.issue1-2en_US
dc.identifier.pmid20701979en_US
dc.identifier.scopus2-s2.0-78449267526en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://doi.org/10.1016/j.jri.2010.06.154
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21837
dc.identifier.volume87en_US
dc.identifier.wosWOS:000285320400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofJournal Of Reproductive Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInterleukin-23en_US
dc.subjectMenstrual Cycleen_US
dc.subjectDeciduaen_US
dc.subjectEndometriumen_US
dc.subjectIl-23en_US
dc.subjectCellsen_US
dc.subjectCytokineen_US
dc.subjectProteinen_US
dc.subjectDifferentiationen_US
dc.subjectProliferationen_US
dc.subjectInflammationen_US
dc.subjectActivationen_US
dc.subjectPromotesen_US
dc.subjectDistincten_US
dc.titleExpression and role of interleukin-23 in human endometrium throughout the menstrual cycle and early pregnancyen_US
dc.typeArticleen_US

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