PROS AND CONS FOR FLUORESCENT IN SITU HYBRIDIZATION, KARYOTYPING AND NEXT GENERATION SEQUENCING FOR DIAGNOSIS AND FOLLOW-UP OF MULTIPLE MYELOMA

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dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridatli, emine ikbal/0000-0001-9003-1449
dc.authoridKalkan, Rasime/0000-0002-6095-7352;
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidatli, emine ikbal/AAN-5060-2020
dc.authorwosidKalkan, Rasime/X-4808-2019
dc.authorwosidDemir, Selma/A-1500-2018
dc.contributor.authorAtli, Ikbal E.
dc.contributor.authorGurkan, H.
dc.contributor.authorKirkizlar, Onur H.
dc.contributor.authorAtli, E.
dc.contributor.authorDemir, S.
dc.contributor.authorYalcintepe, S.
dc.contributor.authorKalkan, R.
dc.date.accessioned2024-06-12T10:59:07Z
dc.date.available2024-06-12T10:59:07Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMultiple myeloma (MM) is one of the plasma cell-related hematological malignancies exceeding 10.0% of all marrow cells, and they make a paraprotein that is a marker of the disease. Myeloma is one of the most common types of hematological malignancies in humans. Genetic biomarkers have been used for prognostic markers in patients diagnosed with MM. The genetic and genomic changes have been identified using karyotyping, fluorescent in situ hybridization (FISH), next generation sequencing (NGS), specifically whole-genome sequencing or exome sequencing. Circulatory plasma cells, circulating free DNA (cfDNA) and microRNAs (miRNAs) comprised in liquid biopsy are potentially used in diagnosis/prognosis of MM. In this study, we analyzed and compared results of karyo-typing, FISH and NGS in 35 MM cases. Diagnostic strategies are expanding rapidly and newly developed NGS-based testing may help the understanding of the complexities of genetic alterations in karyotypically normal cases.en_US
dc.identifier.doi10.2478/bjmg-2020-0020
dc.identifier.endpage63en_US
dc.identifier.issn1311-0160
dc.identifier.issue2en_US
dc.identifier.pmid33816073en_US
dc.identifier.scopus2-s2.0-85103195882en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://doi.org/10.2478/bjmg-2020-0020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20322
dc.identifier.volume23en_US
dc.identifier.wosWOS:000645002500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMacedonian Acad Sciences Artsen_US
dc.relation.ispartofBalkan Journal Of Medical Geneticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytogeneticsen_US
dc.subjectFluorescent In Situ Hybridization (FISH)en_US
dc.subjectMultiple Myelomaen_US
dc.subjectNext Generation Sequencing (NGS)en_US
dc.subjectGeneticsen_US
dc.titlePROS AND CONS FOR FLUORESCENT IN SITU HYBRIDIZATION, KARYOTYPING AND NEXT GENERATION SEQUENCING FOR DIAGNOSIS AND FOLLOW-UP OF MULTIPLE MYELOMAen_US
dc.typeArticleen_US

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