The role of functional imaging in the diagnosis and management of late normal tissue injury

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dc.authoridZhou, Su-Min/0000-0002-7517-9653
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.contributor.authorEvans, Elizabeth S.
dc.contributor.authorHahn, Carol A.
dc.contributor.authorKocak, Zafer
dc.contributor.authorZhou, Su-Min
dc.contributor.authorMarks, Lawrence B.
dc.date.accessioned2024-06-12T11:19:17Z
dc.date.available2024-06-12T11:19:17Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description7th International Conference on Dose, Time, and Fractionation in Radiation Oncology -- SEP 18-20, 2005 -- Madison, WIen_US
dc.description.abstractNormal tissue injury after radiation therapy (RT) can be defined based on either clinical symptoms or laboratory/radiologic tests. In the research setting, functional imaging (eg, single-photon emission computed tomography [SPECT], positron-emission tomography [PET], and magnetic resonance imaging [MRI]) is useful because it provides objective quantitative data such as metabolic activity, perfusion, and soft-tissue contrast within tissues and organs. For RT-induced lung, heart, and parotid gland injury, pre- and post-RT SPECT images can be compared with the dose- and volume-dependent nature of regional injury. In the brain, SPECT can detect changes in perfusion and blood flow post-RT, and PET can detect metabolic changes, particularly to regions of the brain that have received doses above 40 to 50 Gy. On MRI, changes in contrast-enhanced images, T-1 and T-2 relaxation times, and pulmonary vascular resistance at different intervals pre- and post-RT show its ability to detect and distinguish different phases of radiation pneumonitis. Similarly, conventional and diffusion-weighted MRI can be used to differentiate between normal tissue edema, necrosis, and tumor in the irradiated brain, and magnetic resonance spectroscopy can measure changes in compounds, indicative of membrane and neuron disruption. The use of functional imaging is a powerful tool for early detection of RT-induced normal tissue injury, which may be related to long-term clinically significant injury.en_US
dc.description.sponsorshipNCI NIH HHS [R01 CA69579] Funding Source: Medlineen_US
dc.identifier.doi10.1016/j.semradonc.2006.11.003
dc.identifier.endpage80en_US
dc.identifier.issn1053-4296
dc.identifier.issn1532-9461
dc.identifier.issue2en_US
dc.identifier.pmid17395037en_US
dc.identifier.scopus2-s2.0-33947505362en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.1016/j.semradonc.2006.11.003
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25151
dc.identifier.volume17en_US
dc.identifier.wosWOS:000245612300002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofSeminars In Radiation Oncologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMagnetic-Resonance-Spectroscopyen_US
dc.subjectAcute Lymphoblastic-Leukemiaen_US
dc.subjectRadiation-Induced Changesen_US
dc.subjectBreast-Cancer Patientsen_US
dc.subjectDose-Volume Histogramen_US
dc.subjectMalignant Brain-Tumorsen_US
dc.subjectLocal Pulmonary Injuryen_US
dc.subjectLong-Term Survivorsen_US
dc.subjectCell Lung-Canceren_US
dc.subjectQuality-Of-Lifeen_US
dc.titleThe role of functional imaging in the diagnosis and management of late normal tissue injuryen_US
dc.typeConference Objecten_US

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