The effects of nimopidine on platelet aggregation in severe head injury

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dc.authorwosidKILINÇER, Cumhur/C-7969-2014
dc.contributor.authorTatli, M.
dc.contributor.authorGuzel, A.
dc.contributor.authorKilincer, C.
dc.contributor.authorBatun, S.
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description9th International Conference on Cerebral Vasospasm -- JUN 27-30, 2006 -- Istanbul, TURKEYen_US
dc.description.abstractBackground. Severe head injury (SHI) is often associated with traumatic subarachnoid haemorrhage (tSAH), vasospasm, and results in an unfavorable outcome. The aim of this study was to evaluate the effect of nimodipine on platelet aggregation in SHI. Method. This prospective study consisted of 80 patients (53 male, 27 female; ages ranging from 17 years to 65 years, mean: 36.2 years) with severe head injury (Glasgow Coma Score, GCS < 8). All patients received antioedema therapy and prophylactic anticonvulsant. The patients were randomly assigned to either the nimodipine group (2 mg/h continuous infusion for one week) (n = 45) or the control group (n = 35). There were 13 patients with tSAH in the nimodipine group and 10 patients with tSAH in the control group. The platelet aggregation ratio (PAR) was measured on the initial day and the 7(th) day. Higher PAR indicates lower circulating platelet aggregates. Findings. The two groups were well matched for age, sex, mode of injury, neurological status and CT scan findings. In fact, comparison of PAR and GCS in the two treatment groups revealed no difference on the first day. Compared to initial values, the nimodipine group showed a significantly higher PAR value (0.6 +/- 0.1 vs. 0.9 +/- 0.2, p < 0.001) and mean GCS value (7.4 +/- 0.7 vs. 13.7 +/- 1.0, p < 0.001) on the 7(th) day. As a result, on the 7(th) day, the nimodipine group had a significantly higher PAR values (0.7 +/- 0.1 vs. 0.9 +/- 0.2, p < 0.001) and mean GCS (12.3 +/- 1.3 vs. 13.7 +/- 1.0, p < 0.001) as compared to the control group. When the analyses were repeated for the subgroups (the patients with tSAH or contusion) nimodipine showed the same effectiveness. Conclusions. Nimodipine effectively inhibits platelet hyperaggregability in severe head injury patients with or without traumatic subarachnoid haemorrhage. Thus, it may have a potential for use in these patients. However, its effect on long-term outcomes such as death and disability rates and quality of life is still to be determined.en_US
dc.identifier.endpage+en_US
dc.identifier.isbn978-3-211-75717-8
dc.identifier.issn0065-1419
dc.identifier.issn2197-8395
dc.identifier.scopus2-s2.0-77957576755en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage437en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22729
dc.identifier.volume104en_US
dc.identifier.wosWOS:000256013000091en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer-Verlag Wienen_US
dc.relation.ispartofCerebral Vasospasm: New Strategies In Research And Treatmenten_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNimodipineen_US
dc.subjectPlatelet Aggregationen_US
dc.subjectSevere Head Injuryen_US
dc.subjectVasospasmen_US
dc.subjectTraumatic Subarachnoid Hemorrhageen_US
dc.subjectPercussion Brain-Injuryen_US
dc.subjectCerebral Blood-Flowen_US
dc.subjectHemodynamic Depressionen_US
dc.subjectNimodipineen_US
dc.subjectIschemiaen_US
dc.subjectPathophysiologyen_US
dc.titleThe effects of nimopidine on platelet aggregation in severe head injuryen_US
dc.typeConference Objecten_US

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