Prognostic value DCE-MRI parameters in predicting factor disease free survival and overall survival for breast cancer patients
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: The aim of the study is to assess the predictive power of DCE-MRI semi-quantitative parameters during treatment of breast cancer, for disease-free (DFS) and overall survival (OS). Materials and methods: Forty-nine women (age range, 28-84 years; mean, 50.6 years) with breast cancer underwent dynamic contrast enhancement MRI at 1.0 T imaging, using 2D FLASH sequences. Time intensity curves (TICs) were obtained from the regions showing maximal enhancement in subtraction images. Semi-quantitative parameters (TICs; maximal relative enhancement within the first minute, E (max/1); maximal relative enhancement of the entire study, E-max; steepest slope of the contrast enhancement curve; and time to peak enhancement) derived from the DCE-MRI data. These parameters were then compared with presence of recurrence or metastasis, DFS and OS by using Cox regression (proportional hazards model) analysis, linear discriminant analysis. Results: The results from of the 49 patients enrolled into the survival analysis demonstrated that traditional prognostic parameters (tumor size and nodal metastasis) and semi-quantitative parameters (E-max/1, and steepest slope) demonstrated significant differences in survival intervals (p < 0.05). Further Cox regression (proportional hazards model) survival analysis revealed that semi-quantitative parameters contributed the greatest prediction of both DFS, OS in the resulting models (for E-max/1: p = 0.013, hazard ratio 1.022; for stepest slope: p = 0.004, hazard ratio 1.584). Conclusion: This study shows that DCE-MRI has utility predicting survival analysis with breast cancer patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Breast Cancer, DCE-MRI, Prognosis, Survival Analysis, Empirical Analysis, Lymph-Node Status, Cervical-Carcinoma, Radiation-Therapy, Tumor, Angiogenesis, Diagnosis, Grade, Chemotherapy, Enhancement
Kaynak
European Journal Of Radiology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
81
Sayı
5
