CEREBRAL VASOMOTOR REACTIVITY IN FIBROMYALGIA PATIENTS AND ITS RELATIONSHIP TO CENTRAL NEUROPATHIC PAIN

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dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authorwosidKEHAYA, Sezgin/N-9995-2017
dc.authorwosidKEHAYA, Sezgin/P-6106-2019
dc.authorwosidKEHAYA, Sezgin/GVU-6069-2022
dc.contributor.authorGuler, Sibel
dc.contributor.authorKurtoglu, Hakan S.
dc.contributor.authorKehaya, Sezgin
dc.contributor.authorPamuk, Nuri
dc.contributor.authorCelik, Yahya
dc.date.accessioned2024-06-12T11:01:56Z
dc.date.available2024-06-12T11:01:56Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground - Cerebral vasomotor reactivity, defined as the cerebral vasculature response to hypoxia, is not well understood in fibromyalgia (FM) patients. This study investigated the difference in the cerebrovascular reactivity (i.e., responsiveness to hypercapnia was evaluated by use of breath-holding index) to the breath-holding index (BHI) between patients with fibromyalgia and a group of normal controls. Methods - The study included 40 FM patients and 40 healthy subjects. Cerebrovascular reactivity was evaluated using the BHI, which is a nonaggressive, well-tolerated, real-time, reproducible screening method to study cerebral haemodynamics. Insonation depth and basal velocity were symmetrical and not significantly different between the two groups (p>0.05). All patients completed the Revised Fibromyalgia Impact Questionnaire (FIQR), Hospital Anxiety and Depression Scale (HADS), visual analogue scale (VAS), and the somatization subscale of the SCL-90-R symptom checklist. Results - The BHI ranged from 0.30 to 2.20 (mean 1.11 +/- 0.45) in the FM patients and 1.10 to 2.80 (mean 1.90 +/- 0.35) in the control group (p<0.001). Disease duration and right BHIaverage and left BHIaverage values exhibited a significant negative correlation (r=-61377; p<0.001, r=-0.842; p<0.001, respectively). As pain and fatigue scores increased, the right BHIaverage and left BHIaverage values decreased (r=-0.431; p=0.005, r=-0.544; p<0.001, r=-0.341; p=0.031, r=-0.644; p<0.001, respectively). Conclusions - BHI values showed that cerebrovascular reactivity in FM patients decreased in comparison to healthy individuals. BHI decreased as disease duration and severity increased. Cerebrovascular reactivity decreased in FM patients, and this phenomenon should be accepted as an abnormality. Additionally, this outcome may have been the result of a mechanism responsible for central neuropathic pain.en_US
dc.identifier.doi10.18071/isz.69.0341
dc.identifier.endpage348en_US
dc.identifier.issn0019-1442
dc.identifier.issn2498-6208
dc.identifier.issue9-10en_US
dc.identifier.pmid29638096en_US
dc.identifier.scopus2-s2.0-84992488180en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage341en_US
dc.identifier.urihttps://doi.org/10.18071/isz.69.0341
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21086
dc.identifier.volume69en_US
dc.identifier.wosWOS:000384632700008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLiteratura Medicaen_US
dc.relation.ispartofIdeggyogyaszati Szemle-Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibromyalgiaen_US
dc.subjectVasomotor Reactivityen_US
dc.subjectBreath Hold Indexen_US
dc.subjectCentral Sensitizationen_US
dc.subjectNeuropathic Painen_US
dc.titleCEREBRAL VASOMOTOR REACTIVITY IN FIBROMYALGIA PATIENTS AND ITS RELATIONSHIP TO CENTRAL NEUROPATHIC PAINen_US
dc.typeArticleen_US

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