Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats

Basit Öğe Kaydı
dc.authorid0000-0002-9773-5390en_US
dc.contributor.authorGoker, Funda
dc.contributor.authorErsanli, Selim
dc.contributor.authorArisan, Volkan
dc.contributor.authorCevher, Erdal
dc.contributor.authorGuzel, Emine Elif
dc.contributor.authorIssever, Halim
dc.contributor.authorOmer, Beyhan
dc.contributor.authorAltun, Gulay Durmus
dc.contributor.authorMorina, Deniz
dc.contributor.authorYilmaz, Tugba Ekiz
dc.contributor.authorDervisoglu, Elmire
dc.contributor.authorDel Fabbro, Massimo
dc.date.accessioned2019-12-25T11:20:06Z
dc.date.available2019-12-25T11:20:06Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nükleer Tıp Anabilim Dalıen_US
dc.description.abstractObjectiveParathyroid hormone (PTH) enhances bone healing. Strontium ranelate (SR) is an antiresorptive agent that increases bone formation. Reports about combined effects of PTH and SR on local bone regeneration in osteoporotic subjects are limited. We aimed at investigating the efficacy of PTH and SR for promoting new bone formation in critical-sized defects of ovariectomized rats. Materials and MethodsParathyroid hormone- and/or SR-containing poloxamer implant tablets with/without chitosan microparticles were delivered locally to calvarial defects of 90 Wistar rats. Biopsies were analyzed histologically and histomorphometrically at 4 and 8weeks of healing. ResultsHistomorphometry revealed that PTH alone promoted new bone formation at 4weeks but the efficiency declined in 8weeks. There was no positive effect of SR alone on bone formation at 4 or 8weeks. Calvarial defects treated with PTH+SR combinations showed statistically significant greater new bone formation than either treatment alone at both time intervals. Tissue responses were modest and supported the good biocompatibility of the biomaterials used. ConclusionParathyroid hormone and SR combinations can be effective for calvarial bone regeneration of ovariectomized rats. PTH plus SR may have potential use as bone graft material in orthopedic and dental surgery to enhance bone healing and osseointegration.en_US
dc.identifier.citationGöker, F., Ersanlı, S., Arısan, V., Cevher, E., Güzel, E. E., İşsever, H., ... & Dervişoğlu, E. (2018). Combined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized rats. Oral diseases, 24(7), 1255-1269.en_US
dc.identifier.doi10.1111/odi.12895en_US
dc.identifier.endpage1269en_US
dc.identifier.issue7en_US
dc.identifier.pmid29774969en_US
dc.identifier.scopus2-s2.0-85053275709en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1255en_US
dc.identifier.urihttps://doi.org/10.1111/odi.12895
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4964
dc.identifier.volume24en_US
dc.identifier.wosWOS:000444468600014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofOral Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectBone Healingen_US
dc.subjectChitosanen_US
dc.subjectOsteoporosisen_US
dc.subjectOvariectomized Raten_US
dc.subjectParathyroid Hormoneen_US
dc.subjectStrontium Ranelateen_US
dc.subjectChitosan Nanoparticlesen_US
dc.subjectHydroxyapatite Coatingsen_US
dc.subjectPostmenopausal Womenen_US
dc.subjectSynthetic Matrixen_US
dc.subjectMineral Densityen_US
dc.subjectTeriparatideen_US
dc.subjectRegenerationen_US
dc.subjectAlendronateen_US
dc.subjectOsteoporosisen_US
dc.subjectIntermittenten_US
dc.titleCombined effect of parathyroid hormone and strontium ranelate on bone healing in ovariectomized ratsen_US
dc.typeArticleen_US

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu