Indomethacin-induced gastric damage in rats and the protective effect of donkey milk

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dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109;
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorTastekin, Ebru
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorUsta, Ufuk
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorCancilar, Ekrem
dc.contributor.authorPuyan, Fulya Oz
dc.date.accessioned2024-06-12T10:59:44Z
dc.date.available2024-06-12T10:59:44Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction: Indomethacin is an anti-inflammatory drug with clearly known side effects on gastric mucosa. New treatment and side effect prevention methods are being studied. Donkey milk, as a nutritional support, has recently come into the spotlight with its anti-oxidant features, high antibody content and low allergenic properties. In this study, we investigated donkey milk's possible protective effect against acute gastric mucosal damage by indomethacin. Material and methods: Four groups, each composed of 8 rats, were created. Rats in the first and third groups were fed with standard rat chow, while those in the second and fourth groups were additionally fed with 25 mg/kg of donkey milk per day via nasogastric gavage. On the 11th day gastric mucosal damage was induced by oral administration of 30 mg/kg of indomethacin to the rats in groups 3 and 4. Six h later all rats were sacrificed and their stomachs were removed for macroscopic and microscopic evaluation as well as biochemical examination of glutathione (GSH) and malondialdehyde (MDA) levels. Tumor necrosis factor-alpha (TNF-alpha) expression in the gastric mucosa was evaluated immunohistochemically. Results: In the donkey milk-indomethacin group, total area of erosion and degree of linear ulceration were significantly lower than in the standard food-indomethacin group (p < 0.05). Also, GSH levels were increased and MDA levels were decreased significantly in this group. Tumor necrosis factor-alpha expression was more prevalent and stronger in the gastritis group, while lower expression was observed in the donkey milk group. Conclusions: Donkey milk was observed to have significant protective effects against gastric damage induced by indomethacin.en_US
dc.identifier.doi10.5114/aoms.2016.59645
dc.identifier.endpage678en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue3en_US
dc.identifier.pmid29765456en_US
dc.identifier.scopus2-s2.0-85045852966en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage671en_US
dc.identifier.urihttps://doi.org/10.5114/aoms.2016.59645
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20561
dc.identifier.volume14en_US
dc.identifier.wosWOS:000433030200026en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDonkey Milken_US
dc.subjectGastric Damageen_US
dc.subjectProtective Effecten_US
dc.subjectIndomethacinen_US
dc.subjectNonsteroidal Antiinflammatory Drugsen_US
dc.subjectMucosal Injuryen_US
dc.subjectIn-Vitroen_US
dc.subjectFree-Radicalsen_US
dc.subjectL-Carnitineen_US
dc.subjectInflammationen_US
dc.subjectAciden_US
dc.subjectVivoen_US
dc.subjectProanthocyanidinen_US
dc.subjectAntioxidanten_US
dc.titleIndomethacin-induced gastric damage in rats and the protective effect of donkey milken_US
dc.typeArticleen_US

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