Contribution of Metabolic Parameters and Pericolic Fat Stranding on Preoperative 18F-FDG PET/CT in Predicting Post-operative Histopathology and Outcome in Colorectal Cancer

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dc.authoridSoyluoglu, Selin/0000-0003-4473-7138
dc.contributor.authorSoyluoglu, Selin
dc.contributor.authorGunay, Busra Ozdemir
dc.date.accessioned2024-06-12T11:01:45Z
dc.date.available2024-06-12T11:01:45Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurposeWe aimed to investigate the additional value of preoperative PET/CT and reveal relationships between metabolic parameters, pericolic fat stranding finding, postoperative histopathology, and overall survival in colorectal cancer (CRC).MethodsCRC patients who underwent preoperative PET/CT between January 2017-December 2021 were analyzed. Lymph nodes, organ metastases, and metabolic parameters were evaluated from PET/CT. The pericolic fat stranding was evaluated from CT component. Relationships between these factors and postoperative histopathological findings were statistically analyzed. Survival analyses were performed.ResultsNinety-one patients (59 males, 32 females) were included in the study. All tumors showed high FDG uptake (mean SUVmax 19.5 +/- 9.9). SUVmax of the tumor differed significantly at T3 and T4 stages (p = 0.041). A significant correlation was found between MTV, TLG values and the differentiation degree (p = 0.005, 0.003, respectively). PET/CT predicted the N stage with a high accuracy rate (80%). PET/CT found additional metastases that changed treatment decisions in one-third of patients. A relationship was found between tumor length, surgical margin, lymphovascular invasion and pericolic fat stranding. In multivariate analysis, differentiation degree (HR = 26.1, 95%CI 1.672-408.467), MTV (HR = 0.3, 95%CI 0.071-0.841), TLG (HR = 3.5, 95%CI 1.065-11.193), and lymphovascular invasion (HR = 0.2, 95%CI 0.026-0.853, p = 0.033) were independent factors affecting overall survival.ConclusionPreoperative PET/CT contributes to CRC management by detecting additional metastases as well as predicting prognosis and postoperative findings such as T stage, N stage and tumor differentiation. The SUVmax may differentiate between T3 and T4 tumor. Reporting of pericolic fat stranding may contribute to the estimation of lymphatic invasion and positive surgical margin.en_US
dc.identifier.doi10.1007/s13139-023-00808-3
dc.identifier.endpage234en_US
dc.identifier.issn1869-3474
dc.identifier.issn1869-3482
dc.identifier.issue5en_US
dc.identifier.pmid37720878en_US
dc.identifier.scopus2-s2.0-85163063966en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.1007/s13139-023-00808-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20997
dc.identifier.volume57en_US
dc.identifier.wosWOS:001004067400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofNuclear Medicine And Molecular Imagingen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectF-18-FDG PETen_US
dc.subjectPETen_US
dc.subjectCTen_US
dc.subjectFDGen_US
dc.subjectColorectal Canceren_US
dc.subjectColon Canceren_US
dc.subjectPericolic Fat Strandingen_US
dc.subjectTotal Lesion Glycolysisen_US
dc.subjectColon-Canceren_US
dc.subjectPrognostic Valueen_US
dc.subjectF-18-Fdg Peten_US
dc.subjectDiagnostic-Accuracyen_US
dc.subjectRectal-Canceren_US
dc.subjectTumor Volumeen_US
dc.subjectFdg Pet/Cten_US
dc.subjectCten_US
dc.subjectManagementen_US
dc.titleContribution of Metabolic Parameters and Pericolic Fat Stranding on Preoperative 18F-FDG PET/CT in Predicting Post-operative Histopathology and Outcome in Colorectal Canceren_US
dc.typeArticleen_US

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