Risk factors, fractures, and management of pregnancy-associated osteoporosis: a retrospective study of 14 Turkish patients

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dc.authoridDemirbag Kabayel, Derya/0000-0003-1974-8054
dc.authoridAKLEYLEK, CANSU/0000-0002-4703-6903
dc.authoridTuna, Filiz/0000-0002-9563-8028
dc.authoridOzdemir, Hande/0000-0002-1717-9604
dc.authorwosidtuna, filiz/ABD-4110-2020
dc.authorwosidKABAYEL, Derya DEMIRBAG/AAB-3712-2021
dc.contributor.authorTuna, Filiz
dc.contributor.authorAkleylek, Cansu
dc.contributor.authorOzdemir, Hande
dc.contributor.authorKabayel, Derya Demirbag
dc.date.accessioned2024-06-12T11:11:47Z
dc.date.available2024-06-12T11:11:47Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPregnancy-associated osteoporosis (PAO) is a rare but painful disease. The current study aimed to investigate the demographic and clinical features, risk factors, treatment options, and outcomes of Turkish patients with PAO. In our retrospective, cross-sectional, and descriptive study the time to PAO diagnosis was 3.6 months. Pain and loss of height were detected in 78.6% and 28.6% of patients, respectively. As such, 60.6% of patients reported fractures at the thoracic area, 30.3% at the lumbar area, and 9.1% at the sacral area. While 14.3% of patients had optimal vitamin D status during pregnancy, 64.3% had vitamin D deficiency, and 21.4% had vitamin D insufficiency. Of the patients, 21.4% received anticoagulant therapy during their pregnancy. Dual X-ray absorptiometry scans revealed that osteoporosis was predominantly in the trabecular bone (L1-L4 Z-score -2.9, Femur Z score -2.19). Management options included supplements of calcium with vitamin D (93%), weaning the baby (79%), specific treatments for osteoporosis (64%), use of a supportive corset (50%), and exercise (21%), respectively. In addition, after delivery, 35.7% of patients were administered denosumab, 21.4% bisphosphonate, and 7.1% were given teriparatide. Data of the clinical features, treatments, and outcomes of PAO may contribute to early detection and management.en_US
dc.identifier.doi10.1080/09513590.2019.1648417
dc.identifier.endpage242en_US
dc.identifier.issn0951-3590
dc.identifier.issn1473-0766
dc.identifier.issue3en_US
dc.identifier.pmid31385717en_US
dc.identifier.scopus2-s2.0-85070494645en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage238en_US
dc.identifier.urihttps://doi.org/10.1080/09513590.2019.1648417
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22928
dc.identifier.volume36en_US
dc.identifier.wosWOS:000480072600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofGynecological Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOsteoporosisen_US
dc.subjectPainen_US
dc.subjectPregnancyen_US
dc.subjectRisk Factorsen_US
dc.subjectVertebral Fracturesen_US
dc.subjectPostpartum Spinal Osteoporosisen_US
dc.subjectRare Causeen_US
dc.subjectBack-Painen_US
dc.subjectTeriparatideen_US
dc.titleRisk factors, fractures, and management of pregnancy-associated osteoporosis: a retrospective study of 14 Turkish patientsen_US
dc.typeArticleen_US

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