Variants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimens

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dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridFelizardo, Diana Montezuma/0000-0001-9551-4589
dc.authoridSoares, Paula/0000-0001-9607-6998
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridBongiovanni, Massimo/0000-0001-9846-6682
dc.authoridSchmitt, Fernando/0000-0002-3711-8681
dc.authoridSchmitt, Fernando/0000-0003-1006-6946
dc.authorwosidCanberk, Sule/AAL-5645-2020
dc.authorwosidFelizardo, Diana Montezuma/AAF-7197-2021
dc.authorwosidSoares, Paula/B-6054-2008
dc.authorwosidCanberk, Sule/AAM-8781-2020
dc.authorwosidBongiovanni, Massimo/C-3144-2017
dc.authorwosidSchmitt, Fernando/A-5270-2008
dc.contributor.authorCanberk, Sule
dc.contributor.authorMontezuma, Diana
dc.contributor.authorInce, Umit
dc.contributor.authorTastekin, Ebru
dc.contributor.authorSoares, Paula
dc.contributor.authorBongiovanni, Massimo
dc.contributor.authorSchmitt, Fernando C.
dc.date.accessioned2024-06-12T11:12:03Z
dc.date.available2024-06-12T11:12:03Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground:Thyroid cancer accounts for 1% of cancer cases in developed countries, in which papillary thyroid carcinoma (PTC) is the most common type. There are multiple variants of PTC described to date, some of them with aggressive behavior and poor clinical outcome. These variants are well described and accepted in recent guidelines of many international societies, and the prognostic and management implications are well laid out. Due to their established clinical importance and to guide appropriate surgical management, it is now imperative in clinical practice, including cytopathology, to differentiate aggressive variants from nonaggressive ones. This review aims to describe the variants of PTC and to provide a practical algorithmic approach to facilitate the cytological diagnosis of these variants.Summary:Subtyping PTC variants on fine needle aspiration cytology (FNAC) is challenging even for the most experienced cytopathologist. To facilitate a correct subtyping on FNAC, we propose a stepwise approach that is mainly designed for conventional smear methodology. This approach requires first to stratify the lesions into oncocytic and nononcocytic features before analyzing further details in cell morphology and pattern.Key Messages:(1) Subtyping in PTC is possible on cytopathology. (2) The main aim of the cytopathologist is to differentiate aggressive from nonaggressive variants. (3) The subtyping of PTC can help in the surgical management of the patients.en_US
dc.identifier.doi10.1159/000503576
dc.identifier.endpage298en_US
dc.identifier.issn0001-5547
dc.identifier.issn1938-2650
dc.identifier.issue4en_US
dc.identifier.pmid31634886en_US
dc.identifier.startpage288en_US
dc.identifier.urihttps://doi.org/10.1159/000503576
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23018
dc.identifier.volume64en_US
dc.identifier.wosWOS:000548721300004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofActa Cytologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPapillary Thyroid Carcinomaen_US
dc.subjectVariantsen_US
dc.subjectCytopathologyen_US
dc.subjectFine Needle Aspiration Cytologyen_US
dc.subjectThyroiden_US
dc.subjectDiffuse Sclerosing Varianten_US
dc.subjectFine-Needle-Aspirationen_US
dc.subjectEncapsulated Follicular Varianten_US
dc.subjectAggressive Variantsen_US
dc.subjectCell-Carcinomaen_US
dc.subjectHobnail Featuresen_US
dc.subjectCytopathologyen_US
dc.subjectCanceren_US
dc.subjectSmearsen_US
dc.titleVariants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimensen_US
dc.typeReview Articleen_US

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