Desferrioxamine Reduces Oxidative Stress in the Lung Contusion

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosidkaraboga, ihsan/AAZ-9840-2020
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorAyvaz, Suleyman
dc.contributor.authorAksu, Burhan
dc.contributor.authorKaraca, Turan
dc.contributor.authorCemek, Mustafa
dc.contributor.authorKaraboga, Ihsan
dc.contributor.authorInan, Mustafa
dc.date.accessioned2024-06-12T11:17:44Z
dc.date.available2024-06-12T11:17:44Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOur hypothesis in this study is that desferrioxamine (DFX) has therapeutic effects on experimental lung contusions in rats. The rats were divided into four groups (n = 8): control, control+DFX, contusion, and contusion+DFX. In the control+DFX and contusion+DFX groups, 100 mg/kg DFX was given intraperitoneally once a day just after the contusion and the day after the contusion. Contusions led to a meaningful rise in the malondialdehyde (MDA) level in lung tissue. MDA levels in the contusion+DFX group experienced a significant decline. Glutathione levels were significantly lower in the contusion group than in the control group and significantly higher in the contusion+DFX group. Glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels in the contusion group were significantly lower than those in the control group. In the contusion+DFX group, SOD and GPx levels were significantly higher than those in the contusion group. In light microscopic evaluation, the contusion and contusion+DFX groups showed edema, hemorrhage, alveolar destruction, and leukocyte infiltration. However, histological scoring of the contusion+DFX group was significantly more positive than that of the contusion group. The iNOS staining in the contusion group was significantly more intensive than that in all other groups. DFX reduced iNOS staining significantly in comparison to the contusion group. This study showed that DFX reduced oxidative stress in lung contusions in rats and histopathologically ensured the recovery of the lung tissue.en_US
dc.identifier.doi10.1155/2013/376959
dc.identifier.issn1537-744X
dc.identifier.pmid23983631en_US
dc.identifier.scopus2-s2.0-84883179868en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2013/376959
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24815
dc.identifier.wosWOS:000322976400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofScientific World Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBlunt Chest Traumaen_US
dc.subjectPulmonary Contusionen_US
dc.subjectNitric-Oxideen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectHif-1-Alpha Accumulationen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectHydroxyl Radicalsen_US
dc.subjectFenton Reactionen_US
dc.subjectInjuryen_US
dc.subjectGlutathioneen_US
dc.titleDesferrioxamine Reduces Oxidative Stress in the Lung Contusionen_US
dc.typeArticleen_US

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