Oxidative Stress and Total Antioxidant Capacity in Diabetic and Nondiabetic Acute Ischemic Stroke Patients

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorTurgut, Nilda
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:11:54Z
dc.date.available2024-06-12T11:11:54Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFree radical formation is the pivotal mechanism of neuronal injury of ischemic and reperfused brain tissue. In healthy individuals, antioxidant activity counterbalances free radical production, but in the case of ischemia, the balance between reactive oxygen species and antioxidant activity is shifted toward free radicals, causing oxidative stress. The aim of this study is to assess total antioxidant capacity (TAC) and oxidative stress in diabetic and nondiabetic acute stroke patients with 2 different stroke subtypes: large and small vessel disease stroke. Sixty-five acute ischemic stroke patients (29 diabetic and 36 nondiabetic) and 20 age-matched healthy control subjects were recruited in the study Plasma TAC and nitric oxide (NO) metabolite levels (nitrite and nitrate) were measured by enzyme-linked immunosorbent assay. The subtypes of stroke were defined according to Trial of Org 10172 in Acute Stroke Treatment criteria. The main findings of this study are that the TAC and NO levels were significantly higher in diabetic acute stroke patients than in nondiabetic patients and control cases (P < .001 and P < .001, respectively). The TAC and NO levels were higher also in nondiabetic stroke patients than in controls, but the difference did not reach any significance. No difference was found between NO and TAC levels in large and small vessel stroke subtypes of diabetic and nondiabetic patients. The authors conclude that oxidative stress and counterbalancing antioxidant capacity are more pronounced in diabetic acute stroke patients than in nondiabetic acute stroke patients.en_US
dc.identifier.doi10.1177/1076029608323087
dc.identifier.endpage700en_US
dc.identifier.issn1076-0296
dc.identifier.issn1938-2723
dc.identifier.issue6en_US
dc.identifier.pmid18840626en_US
dc.identifier.scopus2-s2.0-75549084890en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage695en_US
dc.identifier.urihttps://doi.org/10.1177/1076029608323087
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22976
dc.identifier.volume15en_US
dc.identifier.wosWOS:000271934800013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOxidative Stressen_US
dc.subjectTotal Antioxidant Capacityen_US
dc.subjectNitric Oxideen_US
dc.subjectIschemic Strokeen_US
dc.subjectFocal Cerebral-Ischemiaen_US
dc.subjectNitric-Oxideen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectReperfusion Injuryen_US
dc.subjectPlasma-Levelsen_US
dc.subjectBrainen_US
dc.subjectHyperglycemiaen_US
dc.subjectDysfunctionen_US
dc.subjectGlucoseen_US
dc.subjectTrialen_US
dc.titleOxidative Stress and Total Antioxidant Capacity in Diabetic and Nondiabetic Acute Ischemic Stroke Patientsen_US
dc.typeArticleen_US

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