The association between DRESS and the diminished numbers of peripheral B lymphocytes and natural killer cells

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dc.authorwosidYazicioglu, Mehtap/AAB-9587-2022
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorYazicioglu, Mehtap
dc.contributor.authorElmas, Reyhan
dc.contributor.authorTurgut, Burhan
dc.contributor.authorGenchallac, Tugba
dc.date.accessioned2024-06-12T10:51:55Z
dc.date.available2024-06-12T10:51:55Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractDrug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced, severe multiorgan system reaction whose exact pathogenesis remains unknown. This study aimed at evaluating specific changes in peripheral blood lymphocyte subtypes associated with DRESS during antibiotic treatment. We analyzed six patients with DRESS. A complete blood count and peripheral blood lymphocytes immunophenotyping were carried out at symptom onset and at follow-up visits. Acute-phase reactants and liver enzymes were measured in all patients. Other tests viral serology, serum immunoglobulin levels, and skin tests were performed when possible. B-cell counts were low in all patients at the onset of DRESS, and natural killer (NK) cells were low in all cases except one. During recovery, B-cell numbers were within a normal range in five patients. In one, there was even a 10-fold increase in B-cell counts, although the level was mildly low after 3 months. NK-cell numbers were within a normal range in three patients. The mean numbers of B cells and NK cells were significantly higher in the second samples compared to the values on admission. Serum IgA and IgM levels were low in one patient. The drug provocation test was positive with cefotaxime in one patient. Viral serology, performed on five patients, was negative. A decrease in B-cell and NK-cell counts was the most consistent finding associated with the onset of antibiotic-induced DRESS in our patients. This immunologic alteration might be a useful predictor of DRESS development.en_US
dc.identifier.doi10.1111/j.1399-3038.2012.01268.x
dc.identifier.endpage296en_US
dc.identifier.issn0905-6157
dc.identifier.issn1399-3038
dc.identifier.issue3en_US
dc.identifier.pmid22432939en_US
dc.identifier.scopus2-s2.0-84859821282en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://doi.org/10.1111/j.1399-3038.2012.01268.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18532
dc.identifier.volume23en_US
dc.identifier.wosWOS:000302934400013en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Allergy And Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibioticsen_US
dc.subjectB Cellen_US
dc.subjectChildrenen_US
dc.subjectDrug-Induced Hypersensitivity Syndromeen_US
dc.subjectDrug Reaction With Eosinophilia And Systemic Symptomsen_US
dc.subjectNatural Killer Cellen_US
dc.subjectSystemic Symptomsen_US
dc.subjectHuman-Herpesvirus-6 Reactivationen_US
dc.subjectClinical-Patternen_US
dc.subjectVancomycinen_US
dc.subjectDiagnosisen_US
dc.subjectDrugsen_US
dc.subjectEosinophiliaen_US
dc.subjectVariabilityen_US
dc.subjectTestsen_US
dc.titleThe association between DRESS and the diminished numbers of peripheral B lymphocytes and natural killer cellsen_US
dc.typeArticleen_US

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