Cytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cells

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dc.authoridDemir, Dicle/0000-0001-9257-5765
dc.authoridSERTTAS, RIZA/0000-0002-7493-0388
dc.authoridkan, yüksel/0000-0002-1095-2326
dc.authoridKIRMIZIBEKMEZ, HASAN/0000-0002-6118-8225
dc.authorwosidDemir, Dicle/P-6867-2019
dc.authorwosidSERTTAS, RIZA/AAG-7463-2020
dc.authorwosidkan, yüksel/CAG-4096-2022
dc.contributor.authorCevik, Dicle
dc.contributor.authorErdogan, Suat
dc.contributor.authorSerttas, Riza
dc.contributor.authorKan, Yuksel
dc.contributor.authorKirmizibekmez, Hasan
dc.date.accessioned2024-06-12T11:02:47Z
dc.date.available2024-06-12T11:02:47Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCytotoxic activity-guided fractionation studies on Glycyrrhiza echinata roots led to the isolation of eight compounds (1-8). Chemical structures of the isolates were identified by NMR and MS analysis. Among the tested molecules, retrochalcones namely echinatin (3) (IC50=23.45-41.83 mu M), licochalcone B (4) (IC50=36.04-39.53 mu M) and tetrahydroxylmethoxychalcone (5) (IC50=7.09-80.81 mu M) were the most active ones against PC3, MCF7 and HepG2 cells. Moreover, 5 exhibited selectivity on prostate cancer cells (SI: 5.19). Hoechst staining and Annexin V/PI binding assays as well as cell cycle analysis on the compounds 3 (23 mu M) and 5 (5 and 7 mu M) demonstrated that these retrochalcones induced apoptosis and significantly suppressed cell cycle in G(1) and G(2)/M phases. Furthermore, 3 and 5 showed antimigratory effects on PC3 cells by wound healing assay. The results indicated that tested retrochalcones most particularly 5 could be potential anticancer drug candidates that prevent proliferation and migration of cancer cells.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey; [220S427]en_US
dc.description.sponsorshipAcknowledgements This study was financially supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project No. 220S427).en_US
dc.identifier.doi10.1002/cbdv.202200589
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue1en_US
dc.identifier.pmid36448364en_US
dc.identifier.scopus2-s2.0-85143773848en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200589
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21391
dc.identifier.volume20en_US
dc.identifier.wosWOS:000896839400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlycyrrhiza Echinataen_US
dc.subjectBioassay-Guided Isolationen_US
dc.subjectRetrochalconeen_US
dc.subjectCytotoxic Activityen_US
dc.subjectApoptosisen_US
dc.subjectFlavonoidsen_US
dc.subjectMechanismsen_US
dc.subjectApoptosisen_US
dc.subjectChalconeen_US
dc.subjectLicoriceen_US
dc.titleCytotoxic and Antimigratory Activity of Retrochalcones from Glycyrrhiza echinata L. on Human Cancer Cellsen_US
dc.typeArticleen_US

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