Genotoxicity of waste anaesthetic gases

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dc.authorwosidBozkurt, Gulcin/A-7599-2018
dc.contributor.authorBozkurt, G
dc.contributor.authorMemis, D
dc.contributor.authorKarabogaz, G
dc.contributor.authorPamukcu, Z
dc.contributor.authorTure, M
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorGunday, I
dc.date.accessioned2024-06-12T10:51:35Z
dc.date.available2024-06-12T10:51:35Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and aim: The possibility of a potential mutagenic or carcinogenic action of chronic exposure to low concentrations of inhalational anaesthetics has been previously studied, with conflicting results. The purpose of this study was to assess whether occupational exposure to waste anaesthetic gases increases genotoxic risk. We examined peripheral lymphocytes from anaesthetists for both sister chromatid exchange (SCE) and for cells with high-frequency SCEs (HFCs). Method: A group of 16 non-smoking anaesthetists with occupational exposure to anaesthetic gases and a sex- and age-matched group matched 16 non-smoking matched physicians without occupational exposure to anaesthetic gases were studied. The participants were also selected on the basis of similar responses to a questionnaire assessing risk of genotoxicity relating to other aspects of life. Result: SCEs, and HFC percentages obtained from the exposed anaesthetists (6.6 +/- 2.4 and 12.2 +/- 15.9) were greater but not statistically significantly so than in the reference group (5.2 +/- 1.6 and 5.9 +/- 10.0). Conclusion: This study does not support the existence of an association between occupational exposure to waste anaesthetic gases and an increase in SCEs in lymphocytes. The nature of our anaesthesia practice suggests exposure was likely to be low. It should be noted that some anaesthetic gases produce lesions that can be efficiently repaired in mitogen-stimulated lymphocytes in vitro but not in circulating lymphocytes.en_US
dc.identifier.doi10.1177/0310057X0203000509
dc.identifier.endpage602en_US
dc.identifier.issn0310-057X
dc.identifier.issn1448-0271
dc.identifier.issue5en_US
dc.identifier.pmid12413259en_US
dc.identifier.scopus2-s2.0-0036799928en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage597en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X0203000509
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18401
dc.identifier.volume30en_US
dc.identifier.wosWOS:000179028600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia And Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnaesthetic Gases : Trace Concentrations Anaesthetic Volatile : Atmospheric Pollutionen_US
dc.subjectAnaesthetist : Risks, Genotoxicityen_US
dc.subjectSister-Chromatid Exchangeen_US
dc.subjectOperating-Room Personnelen_US
dc.subjectOxide-Exposed Primatesen_US
dc.subjectEthylene-Oxideen_US
dc.subjectNitrous-Oxideen_US
dc.subjectCytogenetic Damageen_US
dc.subjectFrequency Cellsen_US
dc.subjectLymphocytesen_US
dc.subjectMutagenicityen_US
dc.subjectAnestheticsen_US
dc.titleGenotoxicity of waste anaesthetic gasesen_US
dc.typeArticleen_US

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