The effects of quercetin on bone minerals, biomechanical behavior, and structure in streptozotocin-induced diabetic rats

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dc.authoridKartal, Murat Emre/0000-0003-3896-3438;
dc.authorwosidKartal, Murat Emre/ABA-8196-2021
dc.authorwosidAltan, Mehmet Fatih/AAN-4643-2021
dc.authorwosidDönmez, Senayi/AAB-8905-2020
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAltan, Mehmet Fatih
dc.contributor.authorDonmez, Senayi
dc.contributor.authorOcakci, Ayse
dc.contributor.authorKartal, Murat Emre
dc.date.accessioned2024-06-12T11:13:20Z
dc.date.available2024-06-12T11:13:20Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis study was designed to investigate the effect of quercetin (QE) on bone minerals and biomechanics in insulin-dependent diabetic rats. Diabetes was induced by 50 mg kg(-1) intraperitoneal streptozotocin (STZ) in a single dose. The rats were randomly allotted into four experimental groups: A (control), B (non-diabetic + QE), C (diabetic), and D (diabetic + QE) each containing 10 animals. The diabetic rats received QE (15 mg kg(-1) day(-1)) for 4 weeks following 8 weeks of STZ injection. Blood samples were taken to determine glucose, insulin, calcium, and magnesium levels. The rats' femora were assessed biomechanically at femoral mid-diaphysis and neck. It was found that QE treatment increased insulin, calcium, and magnesium levels. Three-point bending of the femoral mid-diaphysis and necks showed significantly lower maximum load values (F-max) in animals in the STZ group than the QE + STZ or control groups (p < 0.05). The results support the conclusion that QE treatment may decrease blood glucose and increase plasma insulin, calcium, and magnesium. QE treatment may also be effective in bone mineral metabolism, biomechanical strength, and bone structure in STZ-induced diabetic rats. Copyright (C) 2007 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/cbf.1397
dc.identifier.endpage752en_US
dc.identifier.issn0263-6484
dc.identifier.issn1099-0844
dc.identifier.issue6en_US
dc.identifier.pmid17265531en_US
dc.identifier.scopus2-s2.0-38449102064en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage747en_US
dc.identifier.urihttps://doi.org/10.1002/cbf.1397
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23493
dc.identifier.volume25en_US
dc.identifier.wosWOS:000251002300022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofCell Biochemistry And Functionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectQuercetinen_US
dc.subjectBone Massen_US
dc.subjectBiomechanical Behaviouren_US
dc.subjectDiabetes Mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectBeta-Cell Damageen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectParathyroid-Hormoneen_US
dc.subjectOsteoporosisen_US
dc.subjectFlavonoidsen_US
dc.subjectOsteopeniaen_US
dc.subjectDensityen_US
dc.subjectMechanismsen_US
dc.subjectKaempferolen_US
dc.subjectResorptionen_US
dc.titleThe effects of quercetin on bone minerals, biomechanical behavior, and structure in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US

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