Low Serum Uric Acid Predicts Risk of a Composite Disease Endpoint

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dc.authoridözpamuk karadeniz, fatma/0000-0001-5839-9104
dc.authoridKaradeniz, Yusuf/0000-0002-6113-3259
dc.authoridAltay, Servet/0000-0001-7112-3970
dc.authorwosidCan, Günay/AAB-1669-2020
dc.authorwosidözpamuk karadeniz, fatma/AAC-9156-2022
dc.authorwosidKaradeniz, Yusuf/JAC-5120-2023
dc.authorwosidKaradeniz, Yusuf/AAD-2218-2022
dc.authorwosidAltay, Servet/C-1387-2018
dc.contributor.authorOzpamuk-Karadeniz, Fatma
dc.contributor.authorKaradeniz, Yusuf
dc.contributor.authorKaya, Adnan
dc.contributor.authorAltay, Servet
dc.contributor.authorCan, Gunay
dc.contributor.authorOnat, Altan
dc.date.accessioned2024-06-12T11:14:07Z
dc.date.available2024-06-12T11:14:07Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objectives: Mortality may increase in hypouricemia as well as inhyperuricemia. We assessed the predictive value of low serum uric acid (SUA) levels on the risk of overall mortality or a composite endpoint of death and nonfatal events. Materials and Methods: In 1013 community-based middle-aged adults, free of uncontrolled diabetes and coronary heart disease at baseline, the association of sex-specific SUA tertiles with defined outcomes was evaluated prospectively by logistic regression, stratified to gender and presence of type-2 diabetes, using recent criteria. Results: Totally, 43 deaths and additional incident nonfatal events in 157 cases were recorded at a median 3.4 years' follow-up. Multivariable linear regression disclosed SUA to be significantly associated among non-diabetic individuals positively with creatinine, triglycerides, and body mass index in women further with fasted glucose. In multivariable-adjusted logistic regression analysis, sex-specifically dichotomized baseline uric acid (<5.1 and <4.1 mg/dL vs. higher values) significantly predicted the non-fatal events in the whole sample (relative risk (RR) 1.51 [95% confidence interval (CI) 1.02; 2.26]), as well as in men, while composite endpoint in the whole sample tended to rise (RR 1.38). Compared with the intermediate one, the top and bottom SUA tertiles combined tended to confer mortality risk (RR 2.40 [95% CI 0.89; 6.51]). Adverse outcomes in diabetic women were predicted by tertiles 2 and 3. Conclusions: Inverse association of SUA with adverse outcomes, especially in men, is consistent with the involvement of uric acid mass in autoimmune activation. The positive association of uric acid with adverse outcomes in diabetic women is likely mediated by concomitant high-density lipoprotein dysfunction.en_US
dc.identifier.doi10.3390/medicina57040361
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue4en_US
dc.identifier.pmid33917823en_US
dc.identifier.scopus2-s2.0-85104575306en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/medicina57040361
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23796
dc.identifier.volume57en_US
dc.identifier.wosWOS:000643198500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofMedicina-Lithuaniaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSerum Uric Aciden_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectDiabetic Statusen_US
dc.subjectMortalityen_US
dc.subjectSmoking Statusen_US
dc.subjectTotal Cholesterolen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectHdl Dysfunctionen_US
dc.subjectMortalityen_US
dc.subjectInflammationen_US
dc.subjectAggregationen_US
dc.subjectSmokingen_US
dc.subjectStateen_US
dc.titleLow Serum Uric Acid Predicts Risk of a Composite Disease Endpointen_US
dc.typeArticleen_US

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