Transdermal nicotine patch failed to improve postoperative pain management

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dc.authoridAYDIN, GAYE KAYA/0000-0003-1441-9462
dc.authorwosidAYDIN, GAYE KAYA/ABG-7300-2021
dc.contributor.authorTuran, Alparslan
dc.contributor.authorWhite, Paul F.
dc.contributor.authorKoyuncu, Onur
dc.contributor.authorKaramanlioolu, Beyhan
dc.contributor.authorKaya, Gaye
dc.contributor.authorApfel, Christian C.
dc.date.accessioned2024-06-12T11:19:11Z
dc.date.available2024-06-12T11:19:11Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBACKGROUND: A single 3 mg intranasal dose of nicotine has been reported to have analgesic properties. We designed placebo-controlled study to test the hypothesis that transdermal nicotine (TDN) administered over a 3-day period would decrease postoperative pain and opioid analgesic usage and improve the recovery process after lower abdominal surgery. METHODS: Ninety-seven patients undergoing abdominal hysterectomy procedures were randomly assigned to one of two treatment groups: (1) control group received inert (sham) patches 1 h before and for 2 days after surgery, or the (2) nicotine group received TDN 30 (21 mg nicotine) patches I h before induction of anesthesia and for two additional days after surgery. The anesthetic technique was identical in both groups, and the postoperative assessments included verbal rating scales for pain and sedation, IV patient-controlled analgesia morphine usage, quality of recovery assessment, recovery of bowel function, resumption of normal activities, and patient satisfaction with their pain management. Follow-up evaluations were performed at 1 and 3 mo after the operation to assess late recovery events. RESULTS: Postoperative patient-controlled analgesia morphine usage and pain scores while supine or sitting up, intraoperative fentanyl use, oral analgesic consumption, return of bowel Sounds, and passage of flatus did not differ between the two groups. Although ambulation and hospitalization times, as well as, quality of recovery scores, did not differ, resumption of oral intake was delayed in the nicotine group. Discharge eligibility scores were higher in the nicotine group at 48 and 72 h compared with the control group, but the time to return to work was 19 days in both treatment groups. CONCLUSIONS: Perioperative administration of high-close TDN patch did not improve postoperative pain control or decrease the analgesic requirement after pelvic gynecological surgery. Despite delayed resumption of oral intake, more patients in the nicotine group were ready for discharge at 48 and 72 h after surgery. However, times to resuming activities of daily living were similar in both groups.en_US
dc.description.sponsorshipTrakya University in Trakya, Turkey; McDermott Distinguished Chair; Departmental Start-up Fund; Department of Anesthesia; UCSF; White Mountain Instituteen_US
dc.description.sponsorshipSupported by institutional and departmental sources at Trakya University in Trakya, Turkey (Dr. A.T.), the McDermott Distinguished Chair endowment fund, Departmental Start-up Fund, Department of Anesthesia, UCSF and a nonprofit private foundation, the White Mountain Institute (Dr. P.F.W., President).en_US
dc.identifier.doi10.1213/ane.0b013e31816ba3bb
dc.identifier.endpage1017en_US
dc.identifier.issn0003-2999
dc.identifier.issue3en_US
dc.identifier.pmid18713922en_US
dc.identifier.scopus2-s2.0-51449099190en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1011en_US
dc.identifier.urihttps://doi.org/10.1213/ane.0b013e31816ba3bb
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25089
dc.identifier.volume107en_US
dc.identifier.wosWOS:000258702500050en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInduced Antinociceptionen_US
dc.subjectCigarette-Smokingen_US
dc.subjectInvolvementen_US
dc.subjectRatsen_US
dc.subjectWithdrawalen_US
dc.subjectAgonistsen_US
dc.subjectGenderen_US
dc.subjectMiceen_US
dc.titleTransdermal nicotine patch failed to improve postoperative pain managementen_US
dc.typeArticleen_US

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