Concordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastases

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dc.authoriddülger, onur/0000-0002-1155-7790
dc.authoridBOZKURT, SÜHEYLA UYAR/0000-0002-5947-947X
dc.authoridBozkurtlar, Emine/0000-0002-1034-9236
dc.authoridYumuk, Perran Fulden/0000-0001-8650-299X
dc.authoridBATUR, SEBNEM/0000-0001-6577-8970
dc.authoriddurak, sermin/0000-0001-6741-4345
dc.authoridCicin, Irfan/0000-0002-7584-3868
dc.authorwosidbatur, sebnem/C-5097-2017
dc.authorwosiddülger, onur/AAA-2227-2021
dc.authorwosidBOZKURT, SÜHEYLA UYAR/JVO-9637-2024
dc.authorwosidBozkurtlar, Emine/A-4360-2018
dc.authorwosidYumuk, Perran Fulden/A-6189-2018
dc.contributor.authorBatur, Sebnem
dc.contributor.authorDulger, Onur
dc.contributor.authorDurak, Sermin
dc.contributor.authorYumuk, Perran Fulden
dc.contributor.authorCaglar, Hale Basak
dc.contributor.authorBozkurtlar, Emine
dc.contributor.authorBozkurt, Suheyla
dc.date.accessioned2024-06-12T11:12:56Z
dc.date.available2024-06-12T11:12:56Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractProgrammed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 in primary lung tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed the concordance of PD-L1 expression on tumor cells and tumor-infiltrating lymphocytes (TILs) and CD8(+) TIL intensity between primary lung tumors and synchronous BMs from 24 NSCLC patients. PD-L1, CD3, and CD8 positivity was determined by immunohistochemistry (IHC). PD-L1 scoring was based on the proportion of tumor cells with membranous expression of PD-L1 and the cutoff values <1%, 1-49%, >= 50%. CD3 and CD8 positivity in TILs was evaluated semi-quantitatively and the proportion of CD3+/CD8(+)TILs was determined. PD-L1 expression on tumor cells and TILs was evaluated in relation to CD3+/CD8(+)TIL proportions and the intensity of CD8(+)TILs between the paired primary lung and BM tissues. In the primary lung tumors, PD-L1 positivity was observed in 25%, 37.5%, and 37.5% cases for the cutoff values <1%, 1-49%, >= 50% respectively. PD-L1 expression on tumor cells was strongly correlated between the paired primary lung and BM tissues, in all cutoff groups. However, PD-L1 expression on TILs and the proportion of CD3+/CD8(+)TILs were not strongly correlated in all three groups between the paired primary lung tumors and BMs. The intensity of CD8(+)TILs was concordant in only 54.16% of the paired primary lung tumors and BMs. This study showed a high concordance of PD-L1 expression in neoplastic cells between primary NSCLC and synchronous BMs.en_US
dc.identifier.doi10.17305/bjbms.2019.4474
dc.identifier.endpage335en_US
dc.identifier.issn1512-8601
dc.identifier.issn1840-4812
dc.identifier.issue3en_US
dc.identifier.pmid31999935en_US
dc.identifier.scopus2-s2.0-85086910169en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage329en_US
dc.identifier.urihttps://doi.org/10.17305/bjbms.2019.4474
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23366
dc.identifier.volume20en_US
dc.identifier.wosWOS:000544365100006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevoen_US
dc.relation.ispartofBosnian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectProgrammed Death-Ligand 1en_US
dc.subjectNon-Small-Cell Lung Canceren_US
dc.subjectNSCLCen_US
dc.subjectTumor Immunologyen_US
dc.subjectPD-L1en_US
dc.subjectBrain Metastasisen_US
dc.subjectCD8 Lymphocytesen_US
dc.subjectTumor-Infiltrating Lymphocytesen_US
dc.subjectTilsen_US
dc.subjectTumor-Infiltrating Lymphocytesen_US
dc.subjectAntibodyen_US
dc.subjectSafetyen_US
dc.titleConcordance of PD-L1 expression and CD8+ TIL intensity between NSCLC and synchronous brain metastasesen_US
dc.typeArticleen_US

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