Investigation of cardiac and pulmonar doses in patients with left sided breast cancer treated by radiotherapy with deep inspiration breath hold technique

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dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.contributor.authorParlar, S.
dc.contributor.authorVar, G.
dc.contributor.authorCosar, R.
dc.contributor.authorDogan, M.
dc.contributor.authorOzguven, Y.
dc.contributor.authorNurlu, D.
dc.contributor.authorCemUzal, M.
dc.date.accessioned2024-06-12T11:07:36Z
dc.date.available2024-06-12T11:07:36Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Cardiac disease is a documented risk factor in left breast irradiation. In an attempt to reduce cardiac toxicity, different treatment techniques adapted to respiratory cycle phases have been developed. The aim of this study is to investigate the feasibility of the voluntary breath hold technique when irradiating the left breast in selected patients. Material and Methods: The study included 20 patients with left sided breast cancer. For each patient, two computed tomography (CT) scans were acquired, one with the free breathing (FB) technique and one with the voluntary deep inspiration breath hold (DIBH) technique. Treatment plans were created using a field-in-field intensity-modulated radiation therapy technique. A dosimetric comparison was made between the two techniques for the heart, left anterior descending (LAD) coronary artery, ipsilateral lung and contralateral breast. Results: The average of the mean dose of the heart decreased from 7.7 Gy to 5.8 Gy and V-20(Gy) (%) from 12.8% to 8.3% using the DIBH technique (p=0.009, p<0.001). The DIBH technique demonstrated significantly smaller maximum heart distance (2.0 cm vs. 0.9 cm, p < 0.001) and 8.0% reduction in LAD mean dose. Furthermore, D-mean for the ipsilateral lung was reduced from 12.8 Gy to 12.2 Gy and V-20(Gy) (%) from 25.6% to 22.8%. Conclusion: In the treatment plans made using the DIBH technique, a significant reduction in the radiation dose delivered to the heart has been observed. In order to reduce long-term morbidity and mortality risks from cardiovascular disease affecting the survival of patients with left sided breast cancer, irradiation techniques such as the DIBH should be considered, especially for premenopausal patients.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects (TUBAP) [2013/123]en_US
dc.description.sponsorshipThis work was financially supported by the Trakya University Scientific Research Projects (TUBAP project no: 2013/123).en_US
dc.identifier.doi10.52547/ijrr.20.2.17
dc.identifier.endpage375en_US
dc.identifier.issn2322-3243
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85134153504en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage369en_US
dc.identifier.urihttps://doi.org/10.52547/ijrr.20.2.17
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22092
dc.identifier.volume20en_US
dc.identifier.wosWOS:000829786800016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherIjrr-Iranian Journal Radiation Resen_US
dc.relation.ispartofInternational Journal Of Radiation Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLeft Sided Breast Irradiationen_US
dc.subjectDeep Inspiration Breath Holden_US
dc.subjectCardiac Doseen_US
dc.subjectRadiotherapyen_US
dc.subjectIntensity-Modulated Radiotherapyen_US
dc.subjectHeart-Diseaseen_US
dc.subjectLung-Canceren_US
dc.subjectRadiation-Therapyen_US
dc.subjectUk Heartspareen_US
dc.subjectArc Therapyen_US
dc.subjectWomenen_US
dc.subjectConformityen_US
dc.subjectMortalityen_US
dc.subjectIndexen_US
dc.titleInvestigation of cardiac and pulmonar doses in patients with left sided breast cancer treated by radiotherapy with deep inspiration breath hold techniqueen_US
dc.typeArticleen_US

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