Intravitreal bevacizumab effects on VEGF levels in distant organs: an experimental study

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dc.authoridYilmaz, Nejat/0000-0003-0637-3687
dc.authoridyilmaz, şakir necat/0000-0003-1759-3052
dc.authoridAYAZ, LOKMAN/0000-0002-2876-055X
dc.authorwosidOREKİCİ TEMEL, Gülhan/L-1140-2016
dc.authorwosidYilmaz, Nejat/JMB-6519-2023
dc.authorwosidOzcan Metin, Tuba/HKF-6974-2023
dc.authorwosidyilmaz, şakir necat/AAA-5270-2022
dc.authorwosidTemel, Gülhan/JVZ-0483-2024
dc.authorwosidAYAZ, LOKMAN/K-6716-2013
dc.contributor.authorDinc, Erdem
dc.contributor.authorYildirim, Ozlem
dc.contributor.authorYilmaz, S. Necat
dc.contributor.authorCanacankatan, Necmiye
dc.contributor.authorAyaz, Lokman
dc.contributor.authorOzcan, Tuba
dc.contributor.authorTemel, Gulhan O.
dc.date.accessioned2024-06-12T10:52:10Z
dc.date.available2024-06-12T10:52:10Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to determine the effects of single-dose intravitreal bevacizumab on the levels of vascular endothelial growth factor (VEGF) in serum and distant organs. Methods: Adult New Zealand albino rabbits (n = 40) were divided into experimental and control groups. Experimental rabbits received a single 0.05 ml intravitreal injection of 1.25 mg bevacizumab (Avastin) into the right eye, and control rabbits (n = 8) received no injection. Following injection, group 1 rabbits (n = 8) were sacrificed on day 1, group 2 rabbits (n = 8) on day 7, group 3 rabbits (n = 8) on day 14, and group 4 rabbits (n = 8) on day 28; control rabbits were sacrificed on day 28. After sacrifice, samples of brain, heart, liver, kidney and blood were collected. Levels of VEGF in serum and tissue were measured using enzyme-linked immunosorbent assay. The presence of bevacizumab was evaluated by immunofluorescence staining in tissues. Results: Positive bevacizumab immunoreactivity was observed in brain, heart and kidney. Serum VEGF levels significantly decreased in groups 3 and 4 compared with controls (p < 0.05). Liver VEGF levels significantly decreased in group 3 compared with controls (p < 0.05). Conclusions: Intravitreal bevacizumab not only may escape from the blood-retinal barrier and enter the general circulation, but also may be disseminated to distant organs. Our study demonstrates that a single dose of intravitreally injected bevacizumab decreases VEGF levels in serum and liver.en_US
dc.description.sponsorshipMersin University Scientific Research Fund [BAP-TF CTB (ED) 2011-3 TU]en_US
dc.description.sponsorshipThis study was supported by Mersin University Scientific Research Fund (Grant No: BAP-TF CTB (ED) 2011-3 TU).en_US
dc.identifier.doi10.3109/15569527.2013.855227
dc.identifier.endpage282en_US
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4en_US
dc.identifier.pmid24228870en_US
dc.identifier.scopus2-s2.0-84912083682en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage275en_US
dc.identifier.urihttps://doi.org/10.3109/15569527.2013.855227
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18604
dc.identifier.volume33en_US
dc.identifier.wosWOS:000345498400003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofCutaneous And Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-VEGFen_US
dc.subjectBrainen_US
dc.subjectHearten_US
dc.subjectIntravitreal Bevacizumaben_US
dc.subjectKidneyen_US
dc.subjectLiveren_US
dc.subjectSerumen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectEndothelial Growth-Factoren_US
dc.subjectRetinal Vein Occlusionen_US
dc.subjectAvastin Treatmenten_US
dc.subjectInjectionen_US
dc.subjectPharmacokineticsen_US
dc.subjectRetinopathyen_US
dc.subjectPrematurityen_US
dc.subjectCombinationen_US
dc.subjectSecondaryen_US
dc.subjectTherapyen_US
dc.titleIntravitreal bevacizumab effects on VEGF levels in distant organs: an experimental studyen_US
dc.typeArticleen_US

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