A randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn model

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dc.authoridGungor, Tayfun/0000-0002-7869-9662
dc.authorwosidYilmaz, Bulent/GPK-8613-2022
dc.authorwosidYilmaz, Bulent/HKE-5048-2023
dc.contributor.authorAksakal, Orhan
dc.contributor.authorYilmaz, Bulent
dc.contributor.authorGungor, Tayfun
dc.contributor.authorSirvan, Levent
dc.contributor.authorSut, Necdet
dc.contributor.authorInan, Ismet
dc.contributor.authorKalyoncu, Senol
dc.date.accessioned2024-06-12T10:50:45Z
dc.date.available2024-06-12T10:50:45Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTo investigate the effectiveness of melatonin and rosiglitazone in reducing postoperative adhesion formation in a rat uterine horn model. Thirty non-pregnant female Wistar albino rats, weighing 180-220 g, were used as a model for postoperative adhesion formation. The rats were randomised into three groups after seven standard lesions were inflicted in a 2-cm segment of each uterine horn and lower abdominal sidewall using bipolar cauterisation. The rats were treated with 10 mg/kg, intraperitoneal melatonin, and 1 mg/kg per day peroral rosiglitazone. No medication was given to the control group. As much as 20 uterine horns of 10 rats were evaluated in each group. Extent, severity, and degree of the adhesions to the uterine horns and, inflammation and fibrosis scores (histopathologically) were evaluated after 2 weeks of the treatment. There was no mortality in the groups and all of the rats recovered without incident after operation. Rosiglitazone group had lower adhesion scores [median (min-max ranges)] regarding extent, severity, and degree of the adhesions [0 (0-3), 0 (0-3) and 0 (0-3), respectively], which were significantly different (P < 0.001, P < 0.05 and P < 0.01, respectively) from those of the controls [1 (0-3), 2 (0-2) and 2 (0-3), respectively]; however, there were no statistically significant differences between rosiglitazone versus melatonin groups [1 (0-4), 2 (0-3) and 1 (0-3), respectively] and melatonin versus control groups. Moreover, no significant differences were determined between groups regarding histopathologic findings. Rosiglitazone, but not melatonin, is effective in prevention of adhesion formation in a rat uterine horn model.en_US
dc.identifier.doi10.1007/s00404-009-1240-8
dc.identifier.endpage61en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue1en_US
dc.identifier.pmid19834723en_US
dc.identifier.scopus2-s2.0-77953649302en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage55en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-009-1240-8
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18098
dc.identifier.volume282en_US
dc.identifier.wosWOS:000278520100009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdhesion Preventionen_US
dc.subjectMelatoninen_US
dc.subjectRaten_US
dc.subjectRosiglitazoneen_US
dc.subjectUterine Horn Modelen_US
dc.subjectActivated Receptor-Gammaen_US
dc.subjectHyaluronate/Carboxymethylcellulose Membraneen_US
dc.subjectPeritoneal Adhesionsen_US
dc.subjectPpar-Gammaen_US
dc.subjectPostoperative Adhesionen_US
dc.subjectClinical-Implicationsen_US
dc.subjectOxidative Stressen_US
dc.subjectReductionen_US
dc.subjectPathophysiologyen_US
dc.subjectReperfusionen_US
dc.titleA randomised controlled trial on melatonin and rosiglitazone for prevention of adhesion formation in a rat uterine horn modelen_US
dc.typeArticleen_US

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