Antimicrobial resistance in urosepsis: outcomes from the multinational, multicenter global prevalence of infections in urology (GPIU) study 2003-2013

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dc.authoridBartoletti, Riccardo/0000-0002-0021-0302
dc.authoridbjerklund johansen, truls erik/0000-0003-3490-6460
dc.authorid, Ekaterina/0000-0001-7965-2711
dc.authoridtandogdu, zafer/0000-0002-5309-3656
dc.authoridCai, Tommaso/0000-0002-7234-3526
dc.authoridKoves, Bela/0000-0001-6886-0750
dc.authorwosidBartoletti, Riccardo/HGA-5650-2022
dc.authorwosidKulchavenya, Ekaterina/M-3676-2014
dc.authorwosidCai, Tommaso/AAC-5939-2021
dc.authorwosidNaber, Kurt/AAR-9997-2020
dc.contributor.authorTandogdu, Zafer
dc.contributor.authorBartoletti, Ricardo
dc.contributor.authorCai, Tomasso
dc.contributor.authorCek, Mete
dc.contributor.authorGrabe, Magnus
dc.contributor.authorKulchavenya, Ekaterina
dc.contributor.authorKoves, Bela
dc.date.accessioned2024-06-12T11:16:59Z
dc.date.available2024-06-12T11:16:59Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPrimary objective was to identify the (1) relationship of clinical severity of urosepsis with the pathogen spectrum and resistance and (2) appropriateness of using the pathogen spectrum and resistance rates of health-care-associated urinary tract infections (HAUTI) as representative of urosepsis. The secondary objective was to provide an overview of the pathogens and their resistance profile in patients with urosepsis. A point prevalence study carried out in 70 countries (2003-2013). Population studied included; 408 individuals with microbiologically proven urosepsis, 1606 individuals with microbiological proof of HAUTI and 27,542 individuals hospitalised in urology wards. Main outcomes are pathogens and resistance identified in HAUTIs and urosepsis including its clinical severity. A statistical model that included demographic factors (study year, geographical location, hospital setting) was used for analysis. Amongst urology practices, the prevalence of microbiologically proven HAUTI and urosepsis was 5.8 and 1.5 %, respectively. Frequent pathogens in urosepsis were E. coli (43 %), Enterococcus spp. (11 %), P. aeruginosa (10 %) and Klebsiella spp. (10 %). Resistance to commonly prescribed antibiotics was high and rates ranged from 8 % (imipenem) to 62 % (aminopenicillin/beta lactamase inhibitors); 45 % of Enterobacteriaceae and 21 % of P. aeruginosa were multidrug-resistant. Resistance rates in urosepsis were higher than in other clinical diagnosis of HAUTI (Likelihood ratio < 0.05). It is not appropriate to use the pathogen spectrum and resistance rates of other HAUTIs as representative of urosepsis to decide on empirical treatment of urosepsis. Resistance rates in urosepsis are high, and precautions should be made to avoid further increase.en_US
dc.description.sponsorshipEuropean Association of Urology Research Foundation (EAURF); Cubist Pharmaceuticals (Lexington, MA, USA) via EAURFen_US
dc.description.sponsorshipThe GPIU study is fully funded by European Association of Urology Research Foundation (EAURF). The statistical analysis of this particular GPIU Study database was funded by Cubist Pharmaceuticals (Lexington, MA, USA) via EAURF.en_US
dc.identifier.doi10.1007/s00345-015-1722-1
dc.identifier.endpage1200en_US
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue8en_US
dc.identifier.pmid26658886en_US
dc.identifier.scopus2-s2.0-84949684864en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1193en_US
dc.identifier.urihttps://doi.org/10.1007/s00345-015-1722-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24528
dc.identifier.volume34en_US
dc.identifier.wosWOS:000381101100020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal Of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectUrosepsisen_US
dc.subjectPathogensen_US
dc.subjectResistanceen_US
dc.subjectPrevalenceen_US
dc.subjectUrinary-Tract-Infectionsen_US
dc.subjectSepsisen_US
dc.subjectCareen_US
dc.subjectDefinitionsen_US
dc.subjectAntibioticsen_US
dc.subjectDepartmentsen_US
dc.subjectPerspectiveen_US
dc.subjectPatternsen_US
dc.subjectEuropeen_US
dc.subjectCostsen_US
dc.titleAntimicrobial resistance in urosepsis: outcomes from the multinational, multicenter global prevalence of infections in urology (GPIU) study 2003-2013en_US
dc.typeArticleen_US

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