The analgesic effects of gabapentin after total abdominal hysterectomy

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dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorMemis, D
dc.contributor.authorUsar, P
dc.contributor.authorPamukçu, Z
dc.contributor.authorTüre, M
dc.date.accessioned2024-06-12T11:19:43Z
dc.date.available2024-06-12T11:19:43Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Anesthesia was induced with propofol and maintained with sevoflurane in 50% N2O/O-2 with a fresh gas flow of 2 L/min (50% N2O in O-2) and fentanyl (2 mug/kg). All patients received patient-controlled analgesia with tramadol with a 50 mg initial loading dose, 20 mg incremental dose, 10-min lockout interval, and 4-h limit of 300 mg. The incremental dose was increased to 30 mg if analgesia was inadequate after 1 h. Patients were studied at 4,8,12,16, 20, and 24 h for visual analog (VAS) pain scores, heart rate, peripheral oxygen saturation, mean arterial blood pressure, respiratory rate, sedation, and tramadol consumption. The VAS scores in the sitting and supine position at 1, 4, 8, 12,16, and 20 h were significantly lower in the gabapentin group when compared with the placebo group up to 20 h after surgery. The tramadol consumption at 12, 16, 20, and 24 h and total tramadol consumption were significantly less in the gabapentin group when compared with placebo group. Sedation scores were similar at all the measured times. There were no differences between groups in adverse effects. Preoperative oral gabapentin decreased pain scores and postoperative tramadol consumption in patients after abdominal hysterectomy.en_US
dc.identifier.doi10.1213/01.ANE.0000108964.70485.B2
dc.identifier.endpage1373en_US
dc.identifier.issn0003-2999
dc.identifier.issue5en_US
dc.identifier.pmid15105217en_US
dc.identifier.scopus2-s2.0-1942532988en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1370en_US
dc.identifier.urihttps://doi.org/10.1213/01.ANE.0000108964.70485.B2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25290
dc.identifier.volume98en_US
dc.identifier.wosWOS:000221041800032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAnesthesia And Analgesiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPostoperative Painen_US
dc.subjectAdjunctive Therapyen_US
dc.subjectMorphineen_US
dc.titleThe analgesic effects of gabapentin after total abdominal hysterectomyen_US
dc.typeArticleen_US

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