Protective effects of L-carnitine on myoglobinuric acute renal failure in rats

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dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAydogdu, N
dc.contributor.authorAtmaca, G
dc.contributor.authorYalcin, O
dc.contributor.authorTaskiran, R
dc.contributor.authorTastekin, E
dc.contributor.authorKaymak, K
dc.date.accessioned2024-06-12T10:50:37Z
dc.date.available2024-06-12T10:50:37Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstract1. Muscle injury (rhabdomyolysis) is one of the causes of acute renal failure (ARF). Iron, free radicals and nitric oxide (NO) play a critical role in the pathogenesis of glycerol-induced myoglobinuric ARF. L-Carnitine is an anti-oxidant and prevents the accumulation of end-products of lipid peroxidation. Therefore, the aim of the present study was to investigate the effects of L-carnitine on myoglobinuric ARF induced by intramuscular (i.m.) hypertonic glycerol injection. 2. Sprague-Dawley rats were divided into three groups. Rats in group 1 (n = 8) were given saline, whereas those in groups 2 (n = 10) and 3 (n = 10) were injected with glycerol (10 mL/kg, i.m.). Concomitant with and 24 h after glycerol injection, L-carnitine (200 mg/kg, i.p.) was administered to group 3 rats. Forty-eight hours after glycerol injection, blood samples and kidney tissues were taken from anaesthetised rats. 3. Plasma creatine kinase (CK) activity, urea, creatinine and NO levels, as well as kidney tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme activity and malondialdehyde (MDA) and glutathione (GSH) levels, were determined. In the kidney tissue, histopathological changes and iron accumulation in the tubular epithelium were also investigated. 4. Glycerol treatment caused severe ARF: a marked renal oxidative stress, significantly increased CK activity, urea and creatinine levels and decreased plasma NO levels. Histopathological findings in group 2 rats confirmed that there was renal impairment by cast formation and tubular necrosis and a marked increase in iron accumulation in the tubular epithelium. All these factors were significantly improved by L-carnitine supplementation. 5. These results may indicate that L-carnitine treatment protects against functional, biochemical and morphological damage and iron accumulation in glycerol-induced myoglobinuric ARF in rats. In this model, the protective effect of L-carnitine treatment may provide a new insight into the treatment of rhabdomyolysis-related ARF.en_US
dc.identifier.doi10.1111/j.1440-1681.2006.04336.x
dc.identifier.endpage124en_US
dc.identifier.issn0305-1870
dc.identifier.issn1440-1681
dc.identifier.issue1-2en_US
dc.identifier.pmid16445710en_US
dc.identifier.scopus2-s2.0-33645065107en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage119en_US
dc.identifier.urihttps://doi.org/10.1111/j.1440-1681.2006.04336.x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18068
dc.identifier.volume33en_US
dc.identifier.wosWOS:000235662600019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical And Experimental Pharmacology And Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Renal Failureen_US
dc.subjectAnti-Oxidant Enzymesen_US
dc.subjectL-Carnitineen_US
dc.subjectIronen_US
dc.subjectLipid Peroxidationen_US
dc.subjectNitric Oxideen_US
dc.subjectIronen_US
dc.subjectAciden_US
dc.subjectRhabdomyolysisen_US
dc.subjectGlutathioneen_US
dc.subjectDeliveryen_US
dc.subjectKidneyen_US
dc.subjectInjuryen_US
dc.subjectAssayen_US
dc.titleProtective effects of L-carnitine on myoglobinuric acute renal failure in ratsen_US
dc.typeArticleen_US

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