Cognitive Dysfunction in Chronic Renal Disease: Impact of Dialysis Modality

dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.contributor.authorAk, Recep
dc.contributor.authorUstundag, Sedat
dc.contributor.authorUstundag, Ayten
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T10:58:03Z
dc.date.available2024-06-12T10:58:03Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: Cognitive dysfunction (CD) is common among patients with chronic kidney disease (CKD) and contributes to morbidity and mortality. We aimed to explore the factors involved in the development of CD in patients with CKD and to compare cognitive function between hemodialysis (HD) and peritoneal dialysis (PD) patients. MATERIAL and METHODS: We studied 122 patients with different stages of CKD, and divided them into two groups: Predialysis Group: included 60 CKD patients, (28 stage III and 34 stage IV); Dialysis Group: included 60 patients on dialysis therapy, (30 on HD and 30 on PD). Psychometric tests were done all patients. The results were compared with 41 healthy subjects. RESULTS: We found that the CD rate was higher in patients with CKD (24.6%) than controls (0%, p<0.001). The Mini Mental Test score was found to be correlated with age (r=-0.428), hemoglobin (r=0.336), CRP (r=-0.311), and albumin (r=0.336); the Calculation Test score was found to be correlated with LDL cholesterol (r=-0.336); the Praxis Test Score was found to be correlated with duration of CKD (r=-0.204), HDL (r=0.188); and the Visual Memory Test score was found to be correlated with parathormone levels (r=-0.270). We found the CD rate to be higher in patients on HD (50%) than on PD (23.3%, p=0.032). CONCLUSION: Our findings suggest that anemia, malnutrition and inflammation play an important role in the development of CD in our patients, and cognitive functions are better preserved in the PD group than the HD group.en_US
dc.identifier.doi10.5262/tndt.2015.1003.05
dc.identifier.endpage293en_US
dc.identifier.issn1300-7718
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84943255576en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage283en_US
dc.identifier.urihttps://doi.org/10.5262/tndt.2015.1003.05
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19912
dc.identifier.volume24en_US
dc.identifier.wosWOS:000374928400007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherTurk Nefroloji Diyaliz Transplantasyon Dergisien_US
dc.relation.ispartofTurkish Nephrology Dialysis And Transplantation Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitive Dysfunctionen_US
dc.subjectHemodialysisen_US
dc.subjectPeritoneal Dialysisen_US
dc.subjectChronic Kidney Diseaseen_US
dc.subjectMini-Mental-Stateen_US
dc.subjectPeritoneal-Dialysisen_US
dc.subjectHemodialysisen_US
dc.subjectImpairmenten_US
dc.subjectRecognitionen_US
dc.titleCognitive Dysfunction in Chronic Renal Disease: Impact of Dialysis Modalityen_US
dc.typeArticleen_US

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