Comparison of the protective roles of L-carnitine and amifostine against radiation-induced acute ovarian damage by histopathological and biochemical methods

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dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.contributor.authorYurut-Caloglu, Vuslat
dc.contributor.authorCaloglu, Murat
dc.contributor.authorEskiocak, Sevgi
dc.contributor.authorTastekin, Ebru
dc.contributor.authorOzen, Alaattin
dc.contributor.authorKurkcu, Nukhet
dc.contributor.authorOz-Puyan, Fulya
dc.date.accessioned2024-06-12T10:51:23Z
dc.date.available2024-06-12T10:51:23Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to compare the radioprotective efficacies of L-carnitine (LC) and amifostine against radiation-induced acute ovarian damage. Materials and Methods: Forty-five, 3-month-old Wistar albino rats were randomly assigned to six groups. Control (CONT, n = 7); irradiation alone RT: radiation therapy (RT, n = 8); amifostine plus irradiation (AMI + RT, n = 8); LC plus irradiation (LC + RT, n = 8); LC and sham irradiation (LC, n = 7); and amifostine and sham irradiation (AMI, n = 7). The rats in the AMI + RT, LC + RT and RT groups were irradiated with a single dose of 20 Gy to the whole abdomen. LC (300 mg/kg) and amifostine (200 mg/kg) was given intraperitoneally 30 min before irradiation. Five days after irradiation, both antral follicles and corpus luteum in the right ovaries were counted, and tissue levels of malondialdehyde (MDA) and advanced oxidation protein product (AOPP) were measured. Results: Irradiation significantly decreased antral follicles and corpus luteum (P:0.005 and P < 0.0001). LC increased the median number of antral follicles and corpus luteum (P:0.009 and P < 0.0001, respectively). Amifostine improved median corpus luteum numbers but not antral follicle (P < 0.000, P > 0.05). The level of MDA and AOPP significantly increased after irradiation (P = 0.001 and P < 0.0001, respectively). MDA and AOPP levels were significantly reduced by LC (P:0.003, P < 0.0001) and amifostine (P < 0.0001, P:0.018). When comparing CONT group with AMI + RT and LC + RT groups, MDA and AOPP levels were similar (P > 0.005). The levels of both MDA and AOPP were also similar when LC + RT is compared with AMI + RT group (P > 0.005). Conclusions: L-carnitine and amifostine have a noteworthy and similar radioprotective effect against radiation-induced acute ovarian toxicity.en_US
dc.identifier.doi10.4103/0973-1482.146091
dc.identifier.endpage453en_US
dc.identifier.issn0973-1482
dc.identifier.issn1998-4138
dc.identifier.issue2en_US
dc.identifier.pmid26148616en_US
dc.identifier.scopus2-s2.0-84937143865en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage447en_US
dc.identifier.urihttps://doi.org/10.4103/0973-1482.146091
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18353
dc.identifier.volume11en_US
dc.identifier.wosWOS:000357935800039en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMedknow Publications & Media Pvt Ltden_US
dc.relation.ispartofJournal Of Cancer Research And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectKidneyen_US
dc.subjectIrradiationen_US
dc.subjectL-Carnitineen_US
dc.subjectRadioprotectionen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectOxidative Stressen_US
dc.subjectIrradiationen_US
dc.subjectToxicityen_US
dc.subjectCanceren_US
dc.subjectRatsen_US
dc.subjectDerivativesen_US
dc.subjectWr-2721en_US
dc.subjectAdulten_US
dc.subjectCellsen_US
dc.titleComparison of the protective roles of L-carnitine and amifostine against radiation-induced acute ovarian damage by histopathological and biochemical methodsen_US
dc.typeArticleen_US

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