Prognostic nutritional index and its dynamics after curative treatment are independent prognostic factors on survival in non-metastatic nasopharyngeal carcinoma

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dc.authoridHacioglu, Bekir/0000-0001-8490-3239
dc.authoridSayin, Sezin/0000-0001-7892-5992
dc.authoridKucukarda, Ahmet/0000-0001-7399-2360
dc.authorwosidErdogan, Bulent/AAA-9781-2021
dc.authorwosidKüçükarda, Ahmet/AGF-2120-2022
dc.authorwosidHacioglu, Bekir/GZH-1824-2022
dc.contributor.authorKucukarda, Ahmet
dc.contributor.authorErdogan, Bulent
dc.contributor.authorGokyer, Ali
dc.contributor.authorSayin, Sezin
dc.contributor.authorGokmen, Ivo
dc.contributor.authorOzcan, Erkan
dc.contributor.authorHacioglu, Muhammet Bekir
dc.date.accessioned2024-06-12T11:09:00Z
dc.date.available2024-06-12T11:09:00Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose We aimed to identify the prognostic and predictive values of post-treatment prognostic nutritional index (PNI) and PNI dynamics in nasopharyngeal cancer patients (NPC) in this study. Methods One hundred seven non-metastatic NPC patients were included. PNI was calculated by using the following formula: [10 x serum albumin value (gr/dL)] + [0.005 x total lymphocyte count (per mm3)]. ROC analysis was used for determining prognostic PNI values and univariate and multivariate statistical analyses for prognostic characterization of PNI. Results The statistically significant cut-off values for pre- and post-treatment PNI were 50.65 and 44.75, respectively. Of the pre-treatment PNI analysis, PNI <= 50.65 group had shorter loco-regional recurrence-free survival (LRRFS), distant metastasis-free survival (DMFS), and overall survival (OS). Furthermore, for post-treatment PNI analysis, PNI <= 44.75 group had shorter LRRFS and OS. In univariate analysis, only pre-treatment PNI was associated with LRRFS and DMFS, while pre- and post-treatment PNI were both associated with OS. In multivariate analysis, both PNI were independent prognostic markers for OS. In the combined analysis, pre- and post-treatment PNI, differences between the groups were statistically significant, and the PNI dynamics was an independent prognostic indicator for OS. Conclusion PNI is a useful, independent prognostic marker for non-metastatic NPC patients. It is used for either pre- or post-treatment patients. Furthermore, changes in pre-treatment PNI value after curative treatment is a significant indicator for OS.en_US
dc.identifier.doi10.1007/s00520-021-06627-6
dc.identifier.endpage2139en_US
dc.identifier.issn0941-4355
dc.identifier.issn1433-7339
dc.identifier.issue3en_US
dc.identifier.pmid34677649en_US
dc.identifier.scopus2-s2.0-85117605860en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2131en_US
dc.identifier.urihttps://doi.org/10.1007/s00520-021-06627-6
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22651
dc.identifier.volume30en_US
dc.identifier.wosWOS:000710048500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofSupportive Care In Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNasopharyngeal Canceren_US
dc.subjectPrognostic Nutritional Indexen_US
dc.subjectSurvivalen_US
dc.subjectCanceren_US
dc.subjectSystemen_US
dc.titlePrognostic nutritional index and its dynamics after curative treatment are independent prognostic factors on survival in non-metastatic nasopharyngeal carcinomaen_US
dc.typeArticleen_US

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