Tumor Microenvironment Features as Predictive Biomarkers in Metastatic Differentiated Thyroid Cancer and Their Relationship With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Metabolic Parameters

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dc.authoridKorkmaz, Ulku/0000-0002-7155-7610
dc.authorwosidANDAÇ, BURAK/JEO-6641-2023
dc.authorwosidKorkmaz, Ulku/AAJ-4430-2020
dc.contributor.authorSoyluoglu, Selin
dc.contributor.authorTastekin, Ebru
dc.contributor.authorAndac, Burak
dc.contributor.authorKorkmaz, Ulku
dc.contributor.authorOrun, Seyma Gizem
dc.contributor.authorAltun, Gulay Durmus
dc.date.accessioned2024-06-12T11:16:44Z
dc.date.available2024-06-12T11:16:44Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The role of the tumor microenvironment in tumor progression and treatment response is being investigated for different types of cancer. This study aimed to determine the relationships between tumor microenvironment, histopathology, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based metabolic parameters, treatment response, and overall survival (OS) in metastatic differentiated thyroid cancer (DTC).Methods: Metastatic DTC patients who underwent 18F-FDG PET/CT between 2015-2019 were evaluated. Clinicopathological, histopathological features and PET/CT parameters of patients were recorded. Microenvironmental characteristics of the primary tumor, such as mitosis, intratumoral and peritumoral lymphocytosis, intratumoral and peritumoral fibrosis, were evaluated from the tissue samples. The relationships between these factors were statistically analyzed.Results: Sixty-five patients (38 females, 27 males, age: 49 +/- 15 years) were included. Mitosis, intra/peritumoral lymphocytosis, and intra/peritumoral fibrosis were frequent; however, none of them had a statistically significant association with PET-positive metastases, treatment response, or OS. Univariate analysis showed that gender, size, thyroglobulin values, residual thyroid tissue, PET-positive metastases, and maximum standardized uptake value (SUVmax) were significant predictors of OS. At multivariate analysis, PET-positive metastases (I-IR=-2.65, 95%CI 0.007-0.707, p=0.024) and SUVmax (I-IR=-2.74, 95%CI 0.006-0.687, p=0.023) were the only independent predictors for OS.Conclusion: Our study revealed that microenvironmental characteristics of the primary tumor did not show prognostic significance in metastatic DTC. PET-positive metastases and SUVmax levels were the only significant factors that predicted overall survival in DTC. Supporting the results of our study with further studies with a larger sample size may be necessary to determine the relationship between the tumor microenvironment and prognosis in DTC.en_US
dc.identifier.doi10.7759/cureus.44751
dc.identifier.issn2168-8184
dc.identifier.issue9en_US
dc.identifier.pmid37809246en_US
dc.identifier.urihttps://doi.org/10.7759/cureus.44751
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24430
dc.identifier.volume15en_US
dc.identifier.wosWOS:001085625400010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofCureus Journal Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTumor Microenvironmenten_US
dc.subjectPrognosisen_US
dc.subjectFibrosisen_US
dc.subjectLymphocytosisen_US
dc.subjectPet/Cten_US
dc.subjectThyroid Canceren_US
dc.subjectPapillaryen_US
dc.subjectCarcinomaen_US
dc.subjectInfiltrationen_US
dc.titleTumor Microenvironment Features as Predictive Biomarkers in Metastatic Differentiated Thyroid Cancer and Their Relationship With 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) Metabolic Parametersen_US
dc.typeArticleen_US

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