Prospective evaluation of rickettsioses in the Trakya (European) region of Turkey and atypic presentations of Rickettsia conorii

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dc.authoridRolain, Jean-Marc/0000-0002-2402-4467
dc.authoridRAOULT, Didier/0000-0002-0633-5974
dc.authorwosidRolain, Jean-Marc/Y-3788-2019
dc.authorwosidRAOULT, Didier/A-8434-2008
dc.contributor.authorKuloglu, Figen
dc.contributor.authorRolain, Jean Marc
dc.contributor.authorAydoslu, Baypam
dc.contributor.authorAkata, Filiz
dc.contributor.authorTugrul, Murat
dc.contributor.authorRaoult, Didier
dc.date.accessioned2024-06-12T11:13:42Z
dc.date.available2024-06-12T11:13:42Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description4th International Conference on Rickettsiae and Rickettsial Diseases -- JUN 18-21, 2005 -- Logrono, SPAINen_US
dc.description.abstractIn 2004 between the months of May-November, 11 patients with spotted fever group (SFG) rickettsioses were admitted to the Trakya University Hospital in Edirne, Turkey. SFG rickettsioses were diagnosed clinically. Before treatment, punch biopsy from skin lesions, especially from the eschar, was performed. Serum specimens were tested by 117 using a panel of nine rickettsial antigens, including SFG rickettsiae and R. typhi. Western blotting and standard PCR were also performed. The average age of the 11 patients (4 male and 7 female) was 51 years. All the patients had high fever; 10 (91 %) had maculopapular rash; 8 (73%) had rash in the palms or on the soles. Five patients had a unique eschar; two had double eschars (64%). Two patients presented with multiple organ failure and one of them died. All the patients had significant antibody titers against SFG rickettsiae. PCR experiments of skin biopsies were positive in six (60%) of 10 skin biopsy samples and DNA sequencing of the positive PCR products gave 100% homology with Rickettsia conorii Malish 7 for opmA and gltA. Trakya Region in an endemic area for rickettsioses. In this series, three patients presented with life-threatening diseases and one of them died. This patient was the first fatal case (2.8%). Atypic and serous life-threatening presentations of rickettsioses must be kept in mind for the differential diagnosis of febrile disease in Turkey.en_US
dc.description.sponsorshipGobierno Rioja, Fund Rioja Salud,European Soc Clin Microbiol & Infect Dis,Amer Soc Rickettsiolen_US
dc.identifier.doi10.1196/annals.1374.031
dc.identifier.endpage175en_US
dc.identifier.isbn978-1-57331-639-2
dc.identifier.issn0077-8923
dc.identifier.pmid17114703en_US
dc.identifier.scopus2-s2.0-33845693581en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.1196/annals.1374.031
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23658
dc.identifier.volume1078en_US
dc.identifier.wosWOS:000243594400029en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofCentury Of Rickettsiology: Emerging, Reemerging Rickettsioses, Molecular Diagnostics, And Emerging Veterinary Rickettsiosesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRickettsiosesen_US
dc.subjectTrakya Regionen_US
dc.subjectTurkeyen_US
dc.subjectRickettsia Conoriien_US
dc.titleProspective evaluation of rickettsioses in the Trakya (European) region of Turkey and atypic presentations of Rickettsia conoriien_US
dc.typeConference Objecten_US

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