Single voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomas

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dc.authoridSAV, Aydin/0000-0002-7326-7801
dc.authoridDemir, Mustafa Kemal/0000-0002-7023-6153
dc.authoridDincer, Alp/0000-0001-9158-8353
dc.authoridIplikcioglu, Ahmet Celal/0000-0002-5764-5681
dc.authorwosidDemir, Mustafa/E-2809-2019
dc.authorwosidSAV, Aydin/ABI-3989-2020
dc.authorwosidDincer, Alp/D-3658-2015
dc.contributor.authorDemir, Mustafa Kemal
dc.contributor.authorIplikcioglu, A. Celal
dc.contributor.authorDincer, Alp
dc.contributor.authorArslan, Mahmut
dc.contributor.authorSav, Aydin
dc.date.accessioned2024-06-12T11:08:17Z
dc.date.available2024-06-12T11:08:17Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: To prospectively define proton magnetic resonance spectroscopy (MRS) findings of meningiomas, and describe the ability or inability of short- and long-echo MRS to differentiate typical and atypical meningiomas in vivo. Material and methods: Seventeen patients with pathologically confirmed typical meningiomas and six with atypical meningiomas were evaluated with conventional MR imaging and MRS before resection. MRS studies using point-resolved spectroscopy (PRESS) localisation, at short- and long-echo time (TR 2000 ms, TE: 30 and 144 ms, 64-96 acquisition) were acquired on a 1.5 T scanner. MRS data obtained from these patients were compared with histopathological findings. Mean cellular proliferation (MIB-1) antibody staining against the Ki-67 antigen was also determined in all meningiomas. Results: Prominent choline (Cho) was present in all meningiomas. Alanine (Ala) was observed in 21 cases of the 23 meningiomas. Acetylaspartate (NAA) and creatine (Cr) were either not observed or detected in minimal amounts in at all both groups of meningiomas on long TE (144 ms) spectra. The mean Cho/Cr values in the four atypical meningiomas were 4.44 +/- 0.30 (mean standard deviation) and 3.39 +/- 0.52 in the 12 typical meningiomas on short TE spectra. Cho/Cr ratio could not be determined in the other seven cases because of a lack of creatine peak. Of the five meningiomas in which a lactate peak was detected, four were in typical cases and only one was in atypical meningioma. Mean MIB-1 proliferation index was 3.7% in typical meningiomas and 10% in atypical meningiomas. Conclusion: Prominent Cho, absence or low amount of NAA and Cr, and presence of Ala were common characteristics of spectral pattern of both atypical and typical meningiomas on MRS. MRS cannot reliably differentiate typical intracranial meningiomas from atypical meningiomas preoperatively. Mean MIB-1 proliferation index was well correlated with histopathology findings. (C) 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ejrad.2006.06.002
dc.identifier.endpage55en_US
dc.identifier.issn0720-048X
dc.identifier.issn1872-7727
dc.identifier.issue1en_US
dc.identifier.pmid16844335en_US
dc.identifier.scopus2-s2.0-33748699334en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejrad.2006.06.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22379
dc.identifier.volume60en_US
dc.identifier.wosWOS:000241617200012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofEuropean Journal Of Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMeningiomasen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectMagnetic Resonance Spectroscopyen_US
dc.subjectBrainen_US
dc.subjectAdultsen_US
dc.subjectMagnetic-Resonance Spectroscopyen_US
dc.subjectHuman Brain-Tumorsen_US
dc.subjectMalignant Meningiomasen_US
dc.subjectConsistencyen_US
dc.subjectDiagnosisen_US
dc.subjectPatternsen_US
dc.titleSingle voxel proton MR spectroscopy findings of typical and atypical intracranial meningiomasen_US
dc.typeArticleen_US

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